Association of ICAM3 genetic variant with severe acute respiratory syndrome
Association of ICAM3 genetic variant with severe acute respiratory syndrome
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DOI：
10.1086/518892
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发表时间：
2007-07-15
影响因子：
6.4
通讯作者：
Khoo, Ui-Soon
中科院分区：
文献类型：
--
作者：
Chan, Kelvin Y. K.;Ching, Johannes C. Y.;Khoo, Ui-Soon
Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 ( CD23), an immune response gene, both located on chromosome 19p13.3, were investigated for host genetic susceptibility and association with clinical outcome. A case- control study based on 817 patients with confirmed severe acute respiratory syndrome ( SARS), 307 health care worker control subjects, 290 outpatient control subjects, and 309 household control subjects unaffected by SARS from Hong Kong was conducted to test for genetic association. No significant association to susceptibility to SARS infection caused by the novel coronavirus ( SARS- CoV) was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. However, patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels (; odds ratio [ OR], 4.31 [ 95% confidence interval {CI}, 1.37 - 13.56]) and lower total white Pp. 0067 blood cell counts (; OR, 0.30 [ 95% CI, 0.10 - 0.89]) on admission. These findings support the role of Pp. 022 ICAM3 in the immunopathogenesis of SARS.
