Proteoglycans: key regulators of pulmonary inflammation and the innate immune response to lung infection.
Proteoglycans: key regulators of pulmonary inflammation and the innate immune response to lung infection.
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DOI：
10.1002/ar.21094
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发表时间：
2010-06
影响因子：
2
通讯作者：
Frevert, Charles W.
中科院分区：
文献类型：
--
作者：
Gill, Sean;Wight, Thomas N.;Frevert, Charles W.
关键词：
接触病毒和细菌会导致肺部感染，给公共卫生带来重大负担。先天免疫系统是一种早期预警系统，它识别病毒和细菌，导致炎症介质如细胞因子和趋化因子的快速产生以及白细胞的肺部募集。当白细胞响应于肺部感染而从体循环通过细胞外基质迁移时，它们遇到蛋白聚糖，蛋白聚糖由核心蛋白及其相关的糖胺聚糖组成。本文综述了蛋白多糖如何通过多种不同的机制调节肺部炎症反应和白细胞迁移，包括：1）可溶性蛋白多糖或糖胺聚糖片段激活Toll样受体信号通路的能力; 2）蛋白多糖与细胞因子、趋化因子和生长因子的结合和隔离; 3）蛋白聚糖和透明质酸促进白细胞粘附和隔离的能力;和4）改变这些蛋白酶功能的蛋白聚糖和基质金属蛋白酶之间的相互作用。总之，蛋白多糖通过许多不同的机制微调组织炎症。阐明蛋白多糖调节肺部炎症反应的机制将很可能为炎症性肺病和肺部感染提供新的治疗方法。
Exposure to viruses and bacteria results in lung infections and places a significant burden on public health. The innate immune system is an early warning system that recognizes viruses and bacteria, which results in the rapid production of inflammatory mediators such as cytokines and chemokines and the pulmonary recruitment of leukocytes. When leukocytes emigrate from the systemic circulation through the extracellular matrix in response to lung infection they encounter proteoglycans, which consist of a core protein and their associated glycosaminoglycans. In this review, we discuss how proteoglycans serve to modify the pulmonary inflammatory response and leukocyte migration through a number of different mechanisms including: 1) The ability of soluble proteoglycans or fragments of glycosaminoglycans to activate Toll-like receptor signaling pathways; 2) The binding and sequestration of cytokines, chemokines, and growth factors by proteoglycans; 3) the ability of proteoglycans and hyaluronan to facilitate leukocyte adhesion and sequestration; and 4) The interactions between proteoglycans and matrix metalloproteinases that alter the function of these proteases. In conclusion, proteoglycans fine-tune tissue inflammation through a number of different mechanisms. Clarification of the mechanisms whereby proteoglycans modulate the pulmonary inflammatory response will most likely lead to new therapeutic approaches to inflammatory lung disease and lung infection.
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影响因子：
15.9
作者：
Bode, Lars;Salvestrini, Camilla;Freeze, Hudson H.
通讯作者：
Freeze, Hudson H.
影响因子：
6
作者：
de la Motte, Carol;Nigro, Julie;Stern, Robert
通讯作者：
Stern, Robert
影响因子：
6
作者：
de la Motte, CA;Hascall, VC;Strong, SA
通讯作者：
Strong, SA
DOI：
10.1083/jcb.200106075
发表时间：
2001-11-26
期刊：
The Journal of cell biology
影响因子：
--
作者：
Allen BL;Filla MS;Rapraeger AC
通讯作者：
Rapraeger AC
DOI：
10.1152/ajpgi.00461.2004
发表时间：
2005-05-01
影响因子：
4.5
作者：
Bode, L;Eklund, EA;Freeze, HH
通讯作者：
Freeze, HH