Fertility Programs to Achieve High 21-day Pregnancy Rates in High-Producing Holstein Dairy Herds

Fertility Programs to Achieve High 21-day Pregnancy Rates in High-Producing Holstein Dairy Herds
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旨在提高高产荷斯坦奶牛群 21 天妊娠率的生育计划

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发表时间：
2015
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影响因子：
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通讯作者：
J. Giordano
J. Giordano
中科院分区：
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文献类型：
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作者：
P. Fricke;M. Wiltbank;P. D. Carvalho;J. Giordano

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在Ovsynch方案中，影响生育能力的关键因素是对三种连续激素治疗中每一种的反应，这些激素治疗可以使用孕酮谱来定义。对定时AI具有最高生育力的奶牛在Ovsynch方案的第一次GnRH处理时具有中等水平的孕酮浓度，在PGF 2 α处理时具有高孕酮浓度，在最后一次GnRH处理时具有低孕酮浓度。结合GnRH和PGF2α的组合以严格控制卵巢功能的预排卵策略在Ovsynch方案的第一次GnRH和PGF2α治疗时优化孕酮浓度，从而提高生育力。在低孕酮环境中启动Ovsynch方案的奶牛在第一次GnRH治疗时排卵率很高，但在最后一次GnRH治疗时未能经历完全的黄体退化，导致对定时AI（TAI）的生育力显著降低。在Ovsynch方案中，在第一次治疗后24小时添加第二次PGF 2 α治疗，降低了最后一次GnRH治疗时的孕酮浓度，从而提高了生育力，特别是对于在低孕酮环境中开始Ovsynch的奶牛。一个积极的生殖管理策略，结合这些概念，可以导致一个年化的21天怀孕率超过30%的健康，高产奶牛群。
TAKE HOME MESSAGES  The key factor affecting fertility in an Ovsynch protocol is the response to each of the three sequential hormonal treatments that can be defined using progesterone profiles.  Cows with the greatest fertility to timed AI have mid-level progesterone concentrations at the first GnRH treatment, high progesterone at the PGF2α treatment, and low progesterone at the last GnRH treatment of the Ovsynch protocol.  Presynchronization strategies that incorporate a combination of GnRH and PGF2α to tightly control ovarian function optimize progesterone concentrations at the first GnRH and PGF2α treatments of the Ovsynch protocol, thereby increasing fertility.  Cows that initiate an Ovsynch protocol in a low-progesterone environment ovulate to the first GnRH treatment at a high rate, but fail to undergo complete luteal regression by the last GnRH treatment resulting in dramatically decreased fertility to timed AI (TAI).  Addition of a second PGF2α treatment 24 hours after the first in an Ovsynch protocol decreases progesterone concentrations at the last GnRH treatment, thereby increasing fertility, particularly for cows that initiate Ovsynch in a low-progesterone environment.  An aggressive reproductive management strategy that incorporates these concepts can result in an annualized 21-day pregnancy rate that exceeds 30% in healthy, high-producing dairy herds.