Acute stress impairs spatial memory in male but not female rats: influence of estrous cycle
Acute stress impairs spatial memory in male but not female rats: influence of estrous cycle
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DOI：
10.1016/j.pbb.2004.04.025
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发表时间：
2004-07-01
影响因子：
3.6
通讯作者：
Korol, DL
中科院分区：
文献类型：
--
作者：
Conrad, CD;Jackson, JL;Korol, DL
我们研究了在暴露于急性束缚应激后，性别和发情周期如何影响 Y 迷宫中的空间识别记忆。在实验1中，将完整的雄性和雌性大鼠束缚1小时，然后在开始束缚后2小时，对大鼠进行Y迷宫训练。延迟 4 小时后，评估海马依赖性空间识别记忆。急性压力在两性之间产生相反的模式，男性的空间记忆受损，而女性的空间记忆得到促进。血清皮质酮测量表明，两性在约束后均表现出强烈的皮质酮反应，在 Y 迷宫暴露后表现出中等的皮质酮反应。对约束和 Y 迷宫的反应的血清皮质酮水平在性别之间没有统计学差异。实验2检验了发情周期对急性应激后空间记忆能力的影响。与对照组相比，无论发情周期阶段（发情期和发情前期）如何，急性压力都会促进雌性的空间记忆。此外，与发情期的雌性相比，发情前期的雌性在束缚期间表现出更高的血清皮质酮水平。在基线或从束缚中恢复 2 小时后，未观察到皮质酮水平存在差异。这些数据显示了性别和动情周期如何影响急性压力后的认知功能的重要差异。 (C) 2004 Elsevier Inc. 保留所有权利。
We investigated how sex and estrous cycle influenced spatial recognition memory in the Y-maze after exposure to acute restraint stress. In Experiment 1, intact male and female rats were restrained for 1 h and then 2 h after the start of restraint, rats were trained on the Y-maze. After a 4 h delay, hippocampal-dependent spatial recognition memory was assessed. Acute stress produced opposite patterns between the sexes with spatial memory being impaired in males and facilitated in females. Serum corticosterone measures indicated that both sexes showed a robust corticosterone response after restraint and a moderate corticosterone response after Y-maze exposure. Serum corticosterone levels in response to restraint and Y-maze were not statistically different between the sexes. Experiment 2 examined the influence of the estrous cycle on spatial memory ability after acute stress. Acute stress facilitated spatial memory in females compared to controls, regardless of the estrous cycle phase (estrus and proestrus). Moreover, females in proestrus showed higher serum corticosterone levels during restraint compared to females in estrus. No differences in corticosterone levels were observed at baseline or following 2 h of recovery from restraint. These data show important differences in how sex and estrous cycle influence cognitive functions following acute stress. (C) 2004 Elsevier Inc. All rights reserved.