Differentially Expressed Genes in Matched Normal, Cancer, and Lymph Node Metastases Predict Clinical Outcomes in Patients With Breast Cancer
Differentially Expressed Genes in Matched Normal, Cancer, and Lymph Node Metastases Predict Clinical Outcomes in Patients With Breast Cancer
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DOI：
10.1097/pai.0000000000000717
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发表时间：
2020-02-01
影响因子：
1.6
通讯作者：
Kang, Keunsoo
中科院分区：
文献类型：
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作者：
Kim, Ga-Eon;Kim, Nah Ihm;Kang, Keunsoo
正常、癌症和淋巴结转移的全基因组转录变化筛查为乳腺癌进展和转移的分子基础提供了见解。为了确定BC转移过程中的转录变化和差异表达基因（DEGs），并确定这些DEGs在临床结果中的预后作用，我们通过大规模平行RNA测序比较了7例雌激素受体阳性、her2阴性的BC患者的匹配正常、癌症和淋巴结转移组织的转录组谱。肿瘤和淋巴结转移的基因表达谱呈高度相关(r=0.962， P
Genome-wide screening of transcriptional changes among normal, cancer, and nodal metastases provides insights into the molecular basis of breast cancer (BC) progression and metastasis. To identify transcriptional changes and differentially expressed genes (DEGs) in the metastatic progression of BC and to determine the prognostic role of these DEGs in clinical outcome, we compared transcriptome profiling in matched normal, cancer, and lymph node metastatic tissues of 7 patients with estrogen receptor-positive, HER2-negative BC by using massive parallel RNA sequencing. The global profiles of gene expression in cancer and nodal metastases were highly correlated (r=0.962, P