pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium
pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium
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DOI：
10.1016/j.ijbiomac.2010.03.004
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发表时间：
2010-06-01
影响因子：
8.2
通讯作者：
Wang, Aiqin
中科院分区：
文献类型：
--
作者：
Hua, Shuibo;Ma, Haizhen;Wang, Aiqin
为了提高药物包封率并改善药物递送系统的溶胀行为，采用Ca2+交联和冻融（FT）循环技术制备海藻酸钠/聚（乙烯醇）（SA/PVA）水凝胶珠。 SA和PVA的混合溶液首先与Ca2+交联形成珠子，然后进行冻融循环以进一步交联。通过傅里叶变换红外光谱（FTIR）和X射线衍射（XRD）证实了交联过程。研究了微珠的溶胀和 pH 敏感性，并以双氯芬酸钠为模型药物评估了微珠的载药量和控释性能。结果表明，当PVA与SA的比例为3:1时，珠粒成型良好，包封率大大提高。所开发的珠子的溶胀和降解受到测试介质的pH值和PVA含量的影响。与仅用 Ca2+ 离子交联的纯 SA 微珠相比，FT 工艺提高了药物包封效率，改善了溶胀行为并减缓了药物从双交联微珠中的释放，这为改进药物递送系统提供了一种简便有效的方法。 (C) 2010 Elsevier B.V. 保留所有权利。
In order to enhance the drug entrapment efficiency and improve the swelling behaviors of drug delivery system, Ca2+ crosslinking and freeze-thawing (FT) cycle techniques were used to prepare sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel beads. The mixture solution of SA and PVA was firstly crosslinked with Ca2+ to form beads and then subjected to freezing-thawing cycles for further crosslinking. The crosslinking process was confirmed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The swelling and pH-sensitive properties of the beads were investigated, and the drug loading and controlled release properties of the beads were also evaluated using diclofenac sodium as the model drug. Results indicate that the bead was formed well and the encapsulation efficiency was greatly improved when the ratio of PVA to SA is 3:1. The swelling and degradation of the developed beads was influenced by pH of the test medium and PVA content. FT process enhanced drug entrapment efficiency, improved swelling behaviors and slowed release of drug from the dual crosslinked beads compared with pure SA beads crosslinked with Ca2+ ion alone, which provide a facile and effective method to improve the drug delivery system. (C) 2010 Elsevier B.V. All rights reserved.