Impact of insulin adsorption in various containers during hyperkalaemia treatment.
Impact of insulin adsorption in various containers during hyperkalaemia treatment.
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DOI：
10.1093/ckj/sfab033
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发表时间：
2021-10
影响因子：
4.6
通讯作者：
Curti C
中科院分区：
文献类型：
--
作者：
Robert T;Vanelle P;Brunet P;Martin N;Burtey S;Curti C
高钾血症治疗中的胰岛素-葡萄糖疗法具有安全有效的狭窄治疗指数。我们评估了在高钾血症治疗条件下有效输送胰岛素的变异性。根据我们机构的不同高钾血症治疗程序，使用不同容器（袋或注射器）研究了一系列模拟胰岛素输注。采用自动高效液相色谱法测定胰岛素浓度。我们计算了有效输送的胰岛素，并比较了所有程序之间的时间平均输送胰岛素百分比（TAdi）。与整体容器相比，聚氨酯（PE）袋中的TAdi显著降低至预期胰岛素输注量的63.3%。手术持续时间和胰岛素浓度影响PE和玻璃袋中胰岛素输注的变异性。聚氯乙烯袋的TAdi最高，为93.8%，在此期间没有显著变化。TAdi达到预期胰岛素的90%以上，所有注射器程序均未根据用于稀释胰岛素的溶质发生变化。根据容器的不同，在高钾血症治疗的背景下，静脉注射胰岛素的临床显著差异会发生。丙烯注射器的使用限制了胰岛素输注的变化。在未来，胰岛素-葡萄糖疗法治疗高钾血症的临床研究应详细说明该程序。
Insulin–glucose therapy in hyperkalaemia treatment has a narrow therapeutic index for a safe and efficient use. We assess the variability of the effective delivered insulin under conditions used in the setting of hyperkalaemia treatment. A range of simulated insulin infusions was studied using different containers (bag or syringes) according to the different hyperkalaemia treatment procedures of our institution. Insulin concentration was assayed using a chromatographic method on an automatic high-performance liquid chromatography. We calculated the effective delivered insulin and compared the time average of percentage delivered insulin (TAdi) between all the procedures. The TAdi was significantly decreased to 63.3% of the expected insulin delivery in the polyurethane (PE) bag compared with allover container. The procedure duration and the insulin concentration influenced the variability of the insulin delivery in the PE and glass bag. The polyvinyl chloride bag had the highest TAdi at 93.8%, without significant variation during the time. TAdi reaches ∼90% of the expected insulin with all the syringe procedure without variation according to the solute used to dilute insulin. Clinically significant variations in intravenous insulin delivery occur in the setting of hyperkalaemia treatment according to the container. The use of propylene syringe limits the insulin delivery variation. In the future, clinical studies on hyperkalaemia treatment by insulin–glucose therapy should detail the procedure precisely.
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影响因子：
1.7
作者：
Hewson, MP;Nawadra, V;Simmer, K
通讯作者：
Simmer, K
DOI：
10.1016/j.jpba.2005.10.016
发表时间：
2006-04-11
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Zahid, Najam;Taylor, Kevin M G;Shulman, Rob
通讯作者：
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