Effect of Eucalyptus-Extract Chewing Gum on Oral Malodor: A Double-Masked, Randomized Trial
Effect of Eucalyptus-Extract Chewing Gum on Oral Malodor: A Double-Masked, Randomized Trial
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DOI：
10.1902/jop.2010.100249
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发表时间：
2010-11-01
影响因子：
4.3
通讯作者：
Shizukuishi, Satoshi
中科院分区：
文献类型：
--
作者：
Tanaka, Muneo;Toe, Masahiro;Shizukuishi, Satoshi
背景资料：桉树提取物被发现对一些口腔病原体具有抗菌活性，这些病原体在体外产生口腔恶臭化合物;然而，关于人类口腔恶臭的临床效果尚未得到证实。在本研究中，设计了一项随机临床研究来检验桉树提取物口香糖可以减少普通成年人口腔恶臭的假设。方法：受试者被随机分配到以下三组：高浓度（0.6%桉树提取物）组（n = 32）、低浓度（0.4%桉树提取物）组（n = 32）和安慰剂组（n = 33）。摄入期为12周。在基线和第4、8、12和14周记录感官评分、挥发性硫化合物（VSC）水平和舌苔评分。通过重复测量方差分析（ANOVA）和Games-Howell配对比较检验评价各组间治疗与时间的相互作用。结果：相对于基线读数，高和/或低浓度组的临床参数（包括感官和舌苔评分）在4、8、12和14周时显著降低（P
Background: Eucalyptus extracts were found to possess an antibacterial activity against some oral pathogens that produce oral malodor compounds in vitro; however, the clinical effects with respect to oral malodor in humans remain unproven. In the present investigation, a randomized clinical study was designed to test the hypothesis that eucalyptus-extract chewing gum can reduce oral malodor in the general adult population.Methods: Subjects were randomly assigned to the following three groups: a high-concentration (0.6% eucalyptus extract) group (n = 32), a low-concentration (0.4% eucalyptus extract) group (n = 32), and a placebo group (n = 33). The intake period was 12 weeks. The organoleptic score, level of volatile sulfur compounds (VSCs), and tongue-coating score were recorded at baseline and 4, 8, 12, and 14 weeks. Treatment-to-time interactions among groups were evaluated by repeated-measures analysis of variance (ANOVA) followed by the Games-Howell pairwise comparison test.Results: Relative to baseline readings, significant reductions in clinical parameters, including organoleptic and tongue-coating scores in the high- and/or low-concentration groups, occurred at 4, 8, 12, and 14 weeks (P