A unique set of polypeptides is induced by γ interferon in addition to those induced in common with α and β interferons
A unique set of polypeptides is induced by γ interferon in addition to those induced in common with α and β interferons
复制标题
除了与 α 和 β 干扰素共同诱导的多肽外，γ 干扰素还诱导一组独特的多肽
作者：
J. Weil;Charles J. Epstein;Lois B. Epstein;J. Sedmak;J. L. Sabran;Sidney E. Grossberg
人免疫干扰素（IFN-γ）与白细胞干扰素（IFN-α）和成纤维细胞干扰素（IFN-β）在细胞来源、诱导剂、物理和生物学特性1以及氨基酸序列2方面存在差异。这些差异引起了人们对IFN-γ与IFN-α和IFN-β相比在生物学特性上可能存在差异的兴趣。IFN-γ具有与IFN-α和IFN-β相同的广泛的生物化学和生物学作用，尽管相对效力根据所研究的细胞类型和功能而变化3。到目前为止，还没有直接证据表明IFN-γ改变正常细胞功能不同于其他干扰素1，3。我们在这里报告了与IFN-α和IFN-β相比，人成纤维细胞对IFN-γ的细胞内反应存在显着的定性和定量差异。二维凝胶电泳显示，除了一组常见多肽的诱导外，还存在一组多肽，其合成被IFN-γ独特地诱导。
Human immune interferon (IFN-γ) differs from leukocyte interferon (IFN-α) and fibroblast interferon (IFN-β) in cell origin, inducing agents, physical and biological properties1 and amino acid sequence2. These differences have led to interest in possible differences in the biological properties of IFN-γ compared with IFN-α and IFN-β. IFN-γ has the same broad range of biochemical and biological actions as do IFN-α and IFN-β, although relative potencies vary depending on the cell type and function investigated3. There has so far been no direct evidence that IFN-γ alters normal cell functions differently from other interferons1,3. We report here striking qualitative and quantitative differences in the intracellular response of human fibro-blasts to IFN-γ compared with IFN-α and IFN-β. Two-dimensional gel electrophoresis demonstrates, in addition to the induction of a common group of polypeptides, the existence of a set of polypeptides whose synthesis is uniquely induced by IFN-γ.
小鼠干扰素直接抗细胞活性的增强：相互协同作用和干扰素浓度依赖性。
影响因子：
11.2
作者：
FleischmannJr,WR
通讯作者：
FleischmannJr,WR
正常和 21 号染色体非整倍体人成纤维细胞中干扰素诱导的多肽的合成：与抗病毒测定中相对敏感性的关系。
DOI：
10.1089/jir.1980.1.111
发表时间：
1980
期刊：
Journal of interferon research
影响因子：
--
作者：
Weil,J;Epstein,LB;Epstein,CJ
通讯作者：
Epstein,CJ