Amygdala-prefrontal connectivity during emotion regulation: A meta-analysis of psychophysiological interactions
Amygdala-prefrontal connectivity during emotion regulation: A meta-analysis of psychophysiological interactions
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DOI：
10.1016/j.neuropsychologia.2021.107767
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发表时间：
2021-02-04
期刊：
影响因子：
2.6
通讯作者：
Morawetz, Carmen
中科院分区：
文献类型：
--
作者：
Berboth, Stella;Morawetz, Carmen
鉴于情绪调节在精神病理学发展中作为一个跨诊断因素的重要性，无数的神经影像学研究已经调查了它的神经基础。然而，单一的研究通常对特定大脑区域的功能提供有限的见解。因此，为了更好地理解参与情绪产生和调节的关键区域之间的相互作用，我们对功能磁共振成像（fMRI）研究进行了基于坐标的荟萃分析，该研究使用心理生理相互作用（PPI）分析来检查杏仁核的情绪调节连接。我们使用激活似然估计（ALE）算法分析了15项PPI研究。通过研究独立于调节策略和目标的情绪调节连通性，我们发现杏仁核和左腹外侧前额叶皮层（vlPFC）之间的连接是收敛的，这主要是由PPI研究将重新评估作为一种调节策略所驱动的。一项更有针对性的分析测试表明，在情绪下调过程中，杏仁核与右背外侧前额叶皮层（dlPFC）、左腹外侧前额叶皮层（vlPFC）和背内侧前额叶皮层（dmPFC）之间存在趋同连接。这些前额叶区域与情绪调节过程有关，如工作记忆（dlPFC）、语言过程（vlPFC）和精神状态归因（dmPFC）。我们的研究结果表明，在情绪认知控制过程中，情绪生成和调节系统之间的连接是动态调节的，而且还强调了任务调节前额叶-杏仁核耦合的稳健性，从而为情绪调节的神经衍生模型提供了信息。
Given the importance of emotion regulation as a transdiagnostic factor in the development of psychopathology, a myriad of neuroimaging studies has investigated its neural underpinnings. However, single studies usually provide limited insight into the function of specific brain regions. Hence, to better understand the interaction between key regions involved in emotion generation and regulation, we performed a coordinate-based meta-analysis on functional magnetic resonance imaging (fMRI) studies that examined emotion regulation-modulated connectivity of the amygdala using psychophysiological interaction (PPI) analysis. We analyzed fifteen PPI studies using the activation likelihood estimation (ALE) algorithm. Investigating emotion regulation-modulated connectivity independent of regulation strategy and goal revealed convergent connectivity between the amygdala and the left ventrolateral prefrontal cortex (vlPFC), which was primarily driven by PPI studies implementing reappraisal as a regulation strategy. A more focused analysis testing for effective coupling during the downregulation of emotions by using reappraisal specifically revealed convergent connectivity between the amygdala and the right dorsolateral prefrontal cortex (dlPFC), the left ventrolateral prefrontal cortex (vlPFC), and the dorsomedial prefrontal cortex (dmPFC). These prefrontal regions have been implicated in emotion regulatory processes such as working memory (dlPFC), language processes (vlPFC), and the attribution of mental states (dmPFC). Our findings suggest not only a dynamic modulation of connectivity between emotion generative and regulatory systems during the cognitive control of emotions, but also highlight the robustness of task-modulated prefrontal-amygdala coupling, thereby informing neurally-derived models of emotion regulation.