The Mammalian and Yeast A49 and A34 Heterodimers: Homologous but Not the Same.
The Mammalian and Yeast A49 and A34 Heterodimers: Homologous but Not the Same.
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DOI：
10.3390/genes12050620
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发表时间：
2021-04-22
期刊：
影响因子：
3.5
通讯作者：
Rothblum LI
中科院分区：
文献类型：
--
作者：
McNamar R;Rothblum K;Rothblum LI
核糖体RNA合成是核糖体生物发生的限速步骤。在真核生物中，RNA聚合酶I(POL I)负责转录位于核仁中的核糖体DNA基因。POL I活性的异常与多种癌症和其他遗传性疾病的发生有关。因此，了解Pol I转录的机制是非常关键的。最近的研究表明，Pol I在酵母和哺乳动物中的转录存在许多差异。我们的目标是强调酵母和哺乳动物细胞中聚合酶相关因子(PAF)的异同。我们重点研究了酵母中的PAF异二聚体A49/34和哺乳动物中的PAF53/49。最近的研究表明，虽然酵母和哺乳动物的同源基因结构非常相似，但它们在Pol I转录过程中的功能可能不同，它们的调控模式也不同。
Ribosomal RNA synthesis is the rate-limiting step in ribosome biogenesis. In eukaryotes, RNA polymerase I (Pol I) is responsible for transcribing the ribosomal DNA genes that reside in the nucleolus. Aberrations in Pol I activity have been linked to the development of multiple cancers and other genetic diseases. Therefore, it is key that we understand the mechanisms of Pol I transcription. Recent studies have demonstrated that there are many differences between Pol I transcription in yeast and mammals. Our goal is to highlight the similarities and differences between the polymerase-associated factors (PAFs) in yeast and mammalian cells. We focus on the PAF heterodimer A49/34 in yeast and PAF53/49 in mammals. Recent studies have demonstrated that while the structures between the yeast and mammalian orthologs are very similar, they may function differently during Pol I transcription, and their patterns of regulation are different.
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