Effects of ALO 2145 on intraocular pressure following argon laser trabeculoplasty.
Effects of ALO 2145 on intraocular pressure following argon laser trabeculoplasty.
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ALO 2145 对氩激光小梁成形术后眼压的影响。
DOI：
10.1001/archopht.1987.01060050064039
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发表时间：
1987
影响因子：
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通讯作者：
Cheryl Enger
中科院分区：
文献类型：
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作者：
Alan L. Robin;I. Pollack;Betty House;Cheryl Enger
一项前瞻性、随机、双盲研究比较了局部使用 1% ALO 2145（一种 α2 激动剂）与安慰剂治疗氩激光小梁成形术术后即刻眼内压 (IOP) 升高的情况。使用 80 个 800 至 1000 mW 功率的点对 73 只眼睛（73 名患者）进行了 360 度治疗。术后前三小时、一周和一个月每小时测量眼压升高情况。在术后前三个小时内，与安慰剂治疗的眼睛相比，使用 ALO 2145 治疗的眼睛的平均 IOP 显着降低，并且 IOP 较基线下降幅度更大。使用 ALO 2145 治疗的眼睛和使用安慰剂治疗的 6 只眼睛 (18%) 均未出现 IOP 升高 10 mm Hg 或更高的情况。安慰剂组中的 20 只眼睛 (59%) 和 ALO 2145 治疗组中的 8 只眼睛 (21%) 出现眼压升高。平均心率未检测到变化。 ALO 2145 似乎可以有效消除氩激光小梁成形术后出现的大幅、急性眼压升高。
A prospective, randomized, double-masked study compared topical 1% ALO 2145, an alpha 2-agonist, with placebo in therapy for immediate postoperative intraocular pressure (IOP) rise after argon laser trabeculoplasty. Seventy-three eyes (73 patients) underwent 360 degrees of treatment utilizing 80 spots of 800 to 1000 mW of power. Intraocular pressure rise was measured hourly for the first three hours after operation, at one week, and at one month. Eyes treated with ALO 2145 had both significantly lower mean IOPs and greater IOP decreases from baseline than placebo-treated eyes during the first three hours after operation. No eyes treated with ALO 2145 and six eyes (18%) treated with placebo experienced an IOP rise of 10 mm Hg or greater. Twenty eyes (59%) in the placebo group and eight eyes (21%) treated with ALO 2145 had an IOP elevation. No change was detected in the mean heart rate. ALO 2145 appears to be effective in eliminating large, acute IOP elevations after argon laser trabeculoplasty.