Analyses of factors influencing the acute effect of octreotide in growth hormone-secreting adenomas.
Analyses of factors influencing the acute effect of octreotide in growth hormone-secreting adenomas.
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DOI：
10.1507/endocrj.k08e-305
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发表时间：
2009-04
影响因子：
2
通讯作者：
Michi Nakashima;K. Takano;A. Matsuno
中科院分区：
文献类型：
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作者：
Michi Nakashima;K. Takano;A. Matsuno
奥曲肽等生长抑素类似物通过降低血清生长激素 (GH) 水平来治疗活动性肢端肥大症患者。然而，奥曲肽对 GH 分泌的急性影响因患者而异。为了阐明影响奥曲肽急性效应的因素，我们收集了来自两个机构的 56 名生长激素细胞腺瘤患者的数据。我们分析了以下因素与奥曲肽急性作用的相关性：生长抑素受体亚型2A（SSTR 2A）的免疫组织化学染色、gsp突变的存在、Ki-67染色指数（SI）分析的增殖潜力。我们发现奥曲肽的急性作用与两个因素显着相关：Ki-67 SI 和 SSTR 2A 的质膜主导染色模式。单变量分析显示 Ki-67 SI 与奥曲肽 GH 减少呈统计学显着负相关。我们通过多变量分析评估了每个因素对奥曲肽急性作用的贡献。 p 值为 0.003，证实了显着的多元回归。后测试表明，SSTR 2A 的质膜主导染色模式与奥曲肽减少 GH 显着相关。这些结果表明奥曲肽的急性作用与质膜上的SSTR 2A染色呈正相关。
Somatostatin analogues such as octreotide are used to treat active acromegalic patients by reducing serum growth hormone (GH) levels. However, the acute effect of octreotide on GH secretion differs among patients. To elucidate factors influencing the acute effect of octreotide, we collected data from 56 patients with somatotroph adenoma from two institutions. We analyzed the correlation of the following factors with the acute effect of octreotide: immunohistochemical staining of somatostatin receptor subtype 2A (SSTR 2A), presence of gsp mutation, proliferative potentials analyzed by Ki-67 staining index (SI). We found that the acute effect of octreotide significantly correlated with two factors: Ki-67 SI and the plasma membrane-dominant staining pattern of SSTR 2A. Monovariate analysis revealed a statistically significant inverse relation of Ki-67 SI with the reduction of GH by octreotide. We assessed the contribution of each factor on the acute effect of octreotide by multivariate analysis. Significant multiple regression was confirmed with p value of 0.003. Post-test revealed that the plasma membrane-dominant staining pattern of SSTR 2A was significantly related to the reduction of GH by octreotide. These results show that the acute effect of octreotide is positively related to SSTR 2A staining on the plasma membrane.