Nutritional status and body fat mass: Determinants of sarcopenia in community-dwelling older adults
Nutritional status and body fat mass: Determinants of sarcopenia in community-dwelling older adults
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DOI：
10.1016/j.exger.2019.04.009
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发表时间：
2019-07-15
影响因子：
3.9
通讯作者：
Sohrabi, Zahra
中科院分区：
文献类型：
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作者：
Nasimi, Nasrin;Dabbaghmanesh, Mohammad Hossein;Sohrabi, Zahra
背景：骨质疏松症被定义为以肌肉质量和功能严重下降为特征的老年综合征。本研究旨在探讨老年人骨质疏松症的患病率及其危险因素。骨质疏松症是根据亚洲肉质炎工作组(AWGS)的标准定义的。为了获得骨骼肌质量指数(SMI)，采用生物电阻抗分析(BIA)评估身体成分。分别用握力(HGS)和步速(GS)测量肌肉力量和体能。并对患者的营养状况、体力活动水平、生化指标进行评估。结果：骨质疏松症患病率为20.8%。多因素Logistic回归分析显示，年龄越大、体重指数(BMI)低、血清白蛋白水平越高，低SMI的风险越高。低血清白蛋白水平和年龄也预示着低HGS。此外，高龄、高体脂、低BMI是低血糖的危险因素。反之，增加的小腿围(CC)对低SMI和GS具有保护作用。年龄越大、男性、BMI越低、微型营养评估评分越低、血清白蛋白水平越低、体脂含量越高，发生骨质疏松症的风险越高。结论：老年人骨质疏松症的患病率较高。这项研究强调，营养状况受损和身体脂肪含量高的老年人可能会出现骨质疏松症。进一步的研究可以评估适当的营养干预对石棺减少症的管理和预防的效果。
Background: Sarcopenia is defined as the old age syndrome characterized by profound decline in muscle mass and function. This study aimed to investigate the prevalence of sarcopenia and its risk factors in older adults.Methods: Totally, 501 older people aged 65 years and older were recruited. Sarcopenia was defined according to the criteria of the Asian Working Group for Sarcopenia (AWGS). For obtaining Skeletal Muscle mass Index (SMI), body composition was evaluated using Bioelectrical Impedance Analysis (BIA). Muscle strength and physical performance were measured by Handgrip Strength (HGS) and Gait Speed (GS), respectively. Nutritional status, physical activity level, and biochemical indicators were assessed, as well.Results: The prevalence of sarcopenia was 20.8%. Multiple logistic regression models of the predictors of decline in the components of sarcopenia showed that older age, low Body Mass Index (BMI), and serum albumin level were associated with a higher risk of low SMI. Low serum albumin level and older age were also predictive of low HGS. Besides, old age, high body fat mass, and low BMI were the risk factors of low GS. Conversely, increased Calf Circumference (CC) was protective against low SMI and GS. Finally, older age, male gender, low BMI, decreased mini-nutritional assessment score, low serum albumin level, and high body fat were associated with a higher risk of sarcopenia, whereas higher CC reduced its risk.Conclusion: The prevalence of sarcopenia is high among elderly individuals. This study underlined that sarcopenia might develop in older adults with impaired nutritional status and high body fat mass. Further studies could evaluate the effects of appropriate nutritional interventions on sarcopenia management and prevention.