Leptin increases energy expenditure of a marsupial by inhibition of daily torpor
Leptin increases energy expenditure of a marsupial by inhibition of daily torpor
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DOI：
10.1152/ajpregu.1998.275.5.r1627
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发表时间：
1998-11-01
影响因子：
2.8
通讯作者：
Schmidt, I
中科院分区：
文献类型：
--
作者：
Geiser, F;Körtner, G;Schmidt, I
瘦素在调节胎盘哺乳动物体内脂肪储存中起着重要作用，但能量消耗的变化对这种调节的贡献仍存在争议。我们感兴趣的是，重组鼠瘦素将如何影响代谢率（MR）和体温（Tb）的有袋类哺乳动物（Sminthopsis macroura，25 g），已知显示日常麻木，但缺乏热遗传活性的棕色脂肪组织。在一组8只动物中，在18摄氏度下禁食1天，瘦素治疗使麻木发作的持续时间减半（T-b < 30摄氏度的时间），并使平均每日最小Tb升高4.5摄氏度，最小MR升高2.2倍。因此，瘦素治疗增加了9%的每日能量消耗，虽然MR和Tb在活动阶段没有提高。体重也没有受到影响。有袋类动物的这些发现表明，在休息阶段根据能量可用性调节体温调节能量消耗是瘦素的一个遗传学上古老的功能。
Leptin plays an important role in regulating body fat stores of placental mammals, but the contribution of changes in energy expenditure to this adjustment remains controversial. We were interested in how recombinant murine leptin would affect metabolic rate (MR) and body temperature (Tb) Of a marsupial mammal (Sminthopsis macroura, 25 g) known to display daily torpor but lacking thermogenetically active brown adipose tissue. In a group of eight animals deprived of food for 1 day at 18 degrees C, leptin treatment halved the duration of torpor bouts (time at T-b < 30 degrees C) and raised the average daily minimum Tb by 4.5 degrees C and minimum MR by 2.2-fold. Leptin treatment thus increased daily energy expenditure by 9%, although MR and Tb during the activity phase were not raised. Body mass was also not affected. These findings in a marsupial suggest that the adjustment of thermoregulatory energy expenditure during the rest phase in accordance with energy availability is a phylogenetically old function of leptin.