Photonic Lithotripsy: Near-Infrared Laser Activated Nanomaterials for Kidney Stone Comminution.
Photonic Lithotripsy: Near-Infrared Laser Activated Nanomaterials for Kidney Stone Comminution.
复制标题
DOI：
10.1021/acs.nanolett.3c01166
复制
发表时间：
2023-06
期刊：
影响因子：
10.8
通讯作者：
Ian Houlihan;Benjamin Kang;Smita De;Vijay B. Krishna
中科院分区：
文献类型：
--
作者：
Ian Houlihan;Benjamin Kang;Smita De;Vijay B. Krishna
近红外活化纳米材料已被报道用于生物医学应用，从光热肿瘤破坏到生物膜根除和能量门控药物递送。然而，到目前为止，焦点一直集中在软组织上，而对硬组织的能量输送知之甚少，硬组织的机械强度要高出千倍。我们提出用碳和金纳米材料进行光子碎石术来破碎人类肾结石。石头粉碎的功效取决于纳米材料的尺寸和光子性质。草酸钙的表面重组和分解为碳酸钙支持光热能量对结石破坏的贡献。光子碎石术与当前的激光碎石术相比具有几个优点，包括低操作功率、非接触式激光操作（至少10 mm的距离）以及能够破碎所有常见结石。我们的观察可以激发快速，微创技术的发展，用于肾结石治疗，并外推到其他硬组织，如牙釉质和骨骼。
Near-infrared activated nanomaterials have been reported for biomedical applications ranging from photothermal tumor destruction to biofilm eradication and energy-gated drug delivery. However, the focus so far has been on soft tissues, and little is known about energy delivery to hard tissues, which have thousand-fold higher mechanical strength. We present photonic lithotripsy with carbon and gold nanomaterials for fragmenting human kidney stones. The efficacy of stone comminution is dependent on the size and photonic properties of the nanomaterials. Surface restructuring and decomposition of calcium oxalate to calcium carbonate support the contribution of photothermal energy to stone failure. Photonic lithotripsy has several advantages over current laser lithotripsy, including low operating power, noncontact laser operation (distances of at least 10 mm), and ability to break all common stones. Our observations can inspire the development of rapid, minimally invasive techniques for kidney stone treatment and extrapolate to other hard tissues such as enamel and bone.