Conflict of interest policies for organizations producing a large number of clinical practice guidelines.
Conflict of interest policies for organizations producing a large number of clinical practice guidelines.
复制标题
DOI：
10.1371/journal.pone.0037413
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Fu R
中科院分区：
文献类型：
--
作者：
Norris SL;Holmer HK;Burda BU;Ogden LA;Fu R
临床实践指南 (CPG) 发起者和作者的利益冲突 (COI) 是 CPG 开发中重要的潜在偏差来源。本研究的目的是描述目前生产大量 CPG 的组织的 COI 政策，并确定这些政策是否符合 2011 年医学研究所 (IOM) 标准。我们确定了在 2009 年 1 月 1 日至 2010 年 11 月 5 日期间在国家指南信息交换所中列出了五个或更多指南的组织。我们从可公开访问的来源（通常是该组织的网站）获取了每个组织的 COI 政策，并将这些政策与与 COI 相关的 IOM 标准进行了比较。 37 家组织符合我们的纳入标准，其中 17 家 (46%) 制定了与 CPG 直接相关的 COI 政策。这些利益冲突政策在涉及的利益冲突类型、信息披露对象、披露的货币门槛、管理方法和更新要求方面存在很大差异。没有一个组织的政策符合所审查的所有七项 IOM 标准，并且有 9 个组织没有满足其中一项标准。目前，生产大量 CPG 的组织之间的 COI 政策不符合与 COI 披露和管理相关的 IOM 标准。 CPG 开发者需要对这些政策及其实施进行重大改进，以优化其指南的质量和可信度。
Conflict of interest (COI) of clinical practice guideline (CPG) sponsors and authors is an important potential source of bias in CPG development. The objectives of this study were to describe the COI policies for organizations currently producing a significant number of CPGs, and to determine if these policies meet 2011 Institute of Medicine (IOM) standards. We identified organizations with five or more guidelines listed in the National Guideline Clearinghouse between January 1, 2009 and November 5, 2010. We obtained the COI policy for each organization from publicly accessible sources, most often the organization's website, and compared those polices to IOM standards related to COI. 37 organizations fulfilled our inclusion criteria, of which 17 (46%) had a COI policy directly related to CPGs. These COI policies varied widely with respect to types of COI addressed, from whom disclosures were collected, monetary thresholds for disclosure, approaches to management, and updating requirements. Not one organization's policy adhered to all seven of the IOM standards that were examined, and nine organizations did not meet a single one of the standards. COI policies among organizations producing a large number of CPGs currently do not measure up to IOM standards related to COI disclosure and management. CPG developers need to make significant improvements in these policies and their implementation in order to optimize the quality and credibility of their guidelines.
登录
查看更多内容
影响因子：
158.5
作者：
Campbell, Eric G.;Gruen, Russell L.;Blumenthal, David
通讯作者：
Blumenthal, David
影响因子：
120.7
作者：
Choudhry, NK;Stelfox, HT;Detsky, AS
通讯作者：
Detsky, AS
影响因子：
120.7
作者：
Als-Nielsen, B;Chen, WD;Kjaergard, LL
通讯作者：
Kjaergard, LL
影响因子：
24
作者：
Alpert, JS;Shine, KI;Ofili, E
通讯作者：
Ofili, E