Exclusive consolidated memory phases in Drosophila
Exclusive consolidated memory phases in Drosophila
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DOI：
10.1126/science.1094932
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发表时间：
2004-05-14
期刊：
影响因子：
56.9
通讯作者：
Preat, T
中科院分区：
文献类型：
--
作者：
Isabel, G;Pascual, A;Preat, T
在果蝇中已经描述了两种类型的巩固记忆，麻醉抗性记忆（ARM），一种较短的形式，和稳定的长期记忆（LTM）。到目前为止，人们一直认为ARM和LTM共存。相反，我们表明，LTM的形成会导致ARM的灭绝。没有蘑菇体垂直叶的苍蝇不能形成LTM，但间隔条件反射仍然可以消除他们的ARM，导致一个显着的情况：这些苍蝇训练得越多，他们记得越少。我们建议，ARM作为一个门控机制，确保LTM形成后，只有重复和间隔训练。
Two types of consolidated memory have been described in Drosophila, anesthesia-resistant memory (ARM), a shorter-lived form, and stabilized long-term memory (LTM). Until now, it has been thought that ARM and LTM coexist. On the contrary, we show that LTM formation leads to the extinction of ARM. Flies devoid of mushroom body vertical lobes cannot form LTM, but spaced conditioning can still erase their ARM, resulting in a remarkable situation: The more these flies are trained, the less they remember. We propose that ARM acts as a gating mechanism that ensures that LTM is formed only after repetitive and spaced training.