Modeling the effect of cochlear windows activity on reverse stimulation under the role of physiological third windows
Modeling the effect of cochlear windows activity on reverse stimulation under the role of physiological third windows
复制标题
模拟生理第三窗作用下耳蜗窗活动对反向刺激的影响
DOI：
10.1016/j.apacoust.2020.107473
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发表时间：
2020-12-01
影响因子：
3.4
通讯作者：
Wang, Wenbo
中科院分区：
文献类型：
--
作者：
Liu, Houguang;Xue, Lin;Wang, Wenbo
耳蜗窗由圆形窗(RW)和椭圆形窗(OW)组成。这两个开口连接着耳蜗和中耳；它的活动在声音传递到耳蜗处起着至关重要的作用。然而，很难简单地描述耳蜗窗活动如何影响生理第三窗的反向刺激。在本研究中，一个考虑前庭和耳蜗导水管的混合电路模型被用来研究耳蜗窗活动和反向刺激之间的关系。同时，建立了RW的有限元模型，对RW增厚进行了刚度标定。然后，模拟涉及RW和OW活动的中耳疾病：耳硬化症和中耳炎。最后，计算耳蜗腔内压差传递函数，以预测反向刺激下耳蜗窗活动对声音知觉的影响。结果表明，听觉系统的共振反应使耳蜗窗活动对反向声音传递的影响复杂化。此外，生理性的第三窗产生体积速度分流，这减轻了反向刺激时由于耳蜗窗活动减少而造成的恶化。(C)2020爱思唯尔有限公司。保留所有权利。
The cochlear windows consist of the round window (RW) and the oval window (OW). These two openings connect the cochlea and the middle ear; its activity plays a vital role in sound transmission into the cochlea. However, it is difficult to capture a brief description of how cochlear windows activity affects reverse stimulation with physiological third windows. In the present study, a hybrid circuit model considering the vestibular and cochlear aqueducts was used to investigate the relationship between cochlear windows activity and reverse stimulation. Meanwhile, a finite element (FE) model of the RW was established to perform stiffness calibration on the RW thickening. Then, middle ear disorders involving the activity of the RW and the OW were simulated: otosclerosis and otitis media. Finally, the intracochlear differential pressure transfer function were calculated to predict the influence of cochlear windows activity on sound perception under reverse stimulation. The results show that the resonant response of the auditory system complicates the effects of cochlear windows activity on reverse sound transmission. Moreover, the physiological third windows produce volume velocity shunt flow, which mitigates the deterioration caused by the reduced cochlear windows activity during reverse stimulation. (C) 2020 Elsevier Ltd. All rights reserved.