The Relation between Renal Function and Serum Sclerostin in Adult Patients with CKD
The Relation between Renal Function and Serum Sclerostin in Adult Patients with CKD
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DOI：
10.2215/cjn.07670712
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发表时间：
2013-05-01
影响因子：
9.8
通讯作者：
Fouque, Denis
中科院分区：
文献类型：
--
作者：
Pelletier, Solenne;Dubourg, Laurence;Fouque, Denis
背景与目的：硬化素是一种与骨质疏松症有关的骨抗合成代谢肽，在维持性透析患者中升高。在2010年1月至7月期间，在90名患有CKD的患者中测量血清硬化蛋白和GFR（通过菊粉清除率计算）。同时抽取空腹血样测定钙、磷、甲状旁腺激素、骨碱性磷酸酶和25-羟基维生素D。结果GFR中位数为66.5（四分位数范围，40.0-88.3）ml/min/1.73 m2。中位sclerostin水平为53.5（四分位数范围，37.5-77.2）pmol/L，GFR <10的患者更高。
Background and objectives Sclerostin, a bone antianabolic peptide involved in osteoporosis, is elevated in patients undergoing maintenance dialysis. However, there are no data for patients with early CKD.Design, setting, participants, & measurements Between January and July 2010, serum sclerostin and GFR (calculated by inulin clearance) were measured in 90 patients with CKD. Fasting blood samples were also drawn for determination of calcium, phosphorus, parathyroid hormone, bone alkaline phosphatase, and 25-OH vitamin D.Results Median GFR was 66.5 (interquartile range, 40.0-88.3) ml/min per 1.73 m(2). Median sclerostin level was 53.5 (interquartile range, 37.5-77.2) pmol/L, was higher in patients with a GFR