Mild photothermal therapy/photodynamic therapy/chemotherapy of breast cancer by Lyp-1 modified Docetaxel/IR820 Co-loaded micelles
Mild photothermal therapy/photodynamic therapy/chemotherapy of breast cancer by Lyp-1 modified Docetaxel/IR820 Co-loaded micelles
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DOI：
10.1016/j.biomaterials.2016.08.016
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发表时间：
2016-11-01
期刊：
影响因子：
14
通讯作者：
Qian, ZhiYong
中科院分区：
文献类型：
--
作者：
Li, WenTing;Peng, JinRong;Qian, ZhiYong
患有癌症的患者受益于联合治疗。纳米载体是联合治疗的理想候选者。在本研究中，我们构建了载多西紫杉醇（DTX）胶束纳米药物共载近红外（NIR）染料-IR 820用于光热治疗（PTT）/光动力治疗（PDT）/化疗乳腺癌。将肿瘤归巢肽Lyp-1引入纳米系统，构建主动靶向纳米药物。为了将IR 820递送到肿瘤部位并克服其在体内的短寿命，引入PEI衍生物-PCL-g-PEI。带负电荷的IR 820与胺基形成稳定的静电相互作用，同时IR 820在近红外区的吸收减弱。这表明，在这项研究中构建的纳米系统可能提供一个替代的候选人轻度PIT。通过体内光热转换的评估，我们可以证实IR 820已经成功地递送并有效地积聚在肿瘤部位。此外，该纳米系统的肿瘤细胞靶向和抗癌性能进行了研究，在体外和体内。结果表明，Lyp-1修饰增强了DTX和IR 820的肿瘤靶向递送。通过PIT和PDT的结合，DTX纳米药物有效地抑制了小鼠乳腺癌的生长和转移。这种纳米系统是乳腺癌联合治疗的一个有前途的候选者。(C)2016爱思唯尔有限公司版权所有
Patients suffering from cancer have benefited from combination therapy. Nanocarriers are the ideal candidates for combination therapy. In this study, we constructed docetaxel (DTX) loaded micellar nanomedicines co-loaded with near infrared (NIR) dye-IR820 for photothermal therapy (PTT)/photodynamic therapy (PDT)/chemotherapy of breast cancer. Lyp-1, a tumor homing peptide, was introduced into the nanosystems to construct the active targeting nanomedicine. In order to deliver IR820 to the tumor site and overcome its short lifetime in vivo, a PEI derivative-PCL-g-PEI was introduced. IR820 with negative charge was formed stable static interaction with the amine groups, meanwhile, the absorption of IR820 in the NIR region was weakened. It indicated that the nanosystem constructed in this study may provide an alternative candidate for mild PIT. By the evaluation of the photothermal conversion in vivo, we can confirm that IR820 has been successfully delivered and effectively accumulated in the tumor site. Furthermore, the tumor cells targeting and anticancer performances of this nanosystem have been studied in vitro and in vivo. The results demonstrated Lyp-1 modification has enhanced the tumor targeting delivery of DTX and IR820. By combining PIT and PDT, DTX nanomedicine efficiently inhibited the growth and metastasis of breast cancer in mice. This nanosystem is a promising candidate for combination therapy of breast cancer. (C) 2016 Elsevier Ltd. All rights reserved.