Interleukin-10 polymorphism in position-1082 and acute respiratory distress syndrome
Interleukin-10 polymorphism in position-1082 and acute respiratory distress syndrome
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DOI：
10.1183/09031936.06.00046405
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发表时间：
2006-04-01
影响因子：
24.3
通讯作者：
Christiani, DC
中科院分区：
文献类型：
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作者：
Gong, MN;Thompson, BT;Christiani, DC
白介素10启动子-1082位(-1082GG)的GG基因型与IL-10的产生增加有关。作者假设-1082GG基因与急性呼吸窘迫综合征(ARDS)的发生和转归有关。对211例高加索ARDS病例和429例因败血症、创伤、吸入或大量输血而住进重症监护病房的对照进行了嵌套病例对照研究。对6例患者进行了器官衰竭和60天死亡率的随访。-1082GG基因与ARDS的发生相关，但只有在-1082GG基因与年龄之间存在显著交互作用的情况下。在ARDS患者中，-1082GG基因与入院时病情严重程度降低、日常器官功能障碍评分和60天死亡率降低相关。结论，高IL-10产生-1082GG基因可能与急性呼吸窘迫综合征发生的不同年龄相关。在急性呼吸窘迫综合征患者中，-1082GG基因与较低的死亡率和器官衰竭相关。需要进一步的研究来证实这些发现。
The GG genotype of the interleukin (IL)-10 promoter polymorphism in position -1082 (-1082GG) has been associated with increased IL-10 production. The current authors hypothesised that the -1082GG genotype is associated with the development of, and outcomes in, acute respiratory distress syndrome (ARDS).A nested case-control study was conducted in 211 Caucasian cases of ARDS and 429 controls who were admitted to an intensive care unit with sepsis, trauma, aspiration or massive transfusions. Cases were followed for organ failure and 60-day mortality.The -1082GG genotype was associated with the development of ARDS, but only in the presence of a significant interaction between the -1082GG genotype and age. Among patients with ARDS, the -1082GG genotype was associated with decreased severity of illness on admission, lower daily organ dysfunction scores and lower 60-day mortality.In conclusion, the high interleukin-10-producing -1082GG genotype may be associated with variable odds for acute respiratory distress syndrome development depending on age. Among those with acute respiratory distress syndrome, the -1082GG genotype is associated with lower mortality and organ failure. Further studies are needed to confirm these findings.