HIV Type 1 Molecular Epidemiology among High-Risk Clients Attending the Thai Red Cross Anonymous Clinic in Bangkok, Thailand
HIV Type 1 Molecular Epidemiology among High-Risk Clients Attending the Thai Red Cross Anonymous Clinic in Bangkok, Thailand
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DOI：
10.1089/aid.2009.0150
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发表时间：
2010-01-01
影响因子：
1.5
通讯作者：
de Souza, Mark
中科院分区：
文献类型：
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作者：
Arroyo, Miguel A.;Phanuphak, Nittaya;de Souza, Mark
几项研究报告了泰国高危人群中非CRF 01_AE感染的数量增加，表明HIV-1流行更为复杂。这项研究评估了2006年7月1日至2007年2月28日期间在泰国红十字会匿名诊所（TRCAC）接受HIV-1检测的高危客户中HIV流行的复杂性。通过多区域杂交试验（MHAbce，第2版）从感染受试者（n=401）的血浆中确定HIV-1基因型。采用单变量和多变量logistic回归分析确定与HIV流行率和非CRF 01_AE感染相关的危险因素。艾滋病毒总感染率估计为14.1%：男男性行为者为25.3%，异性恋妇女为18.4%，异性恋男子为9.6%。与艾滋病流行相关的危险因素包括年龄（25-29岁）、危险行为（MSM）、婚姻状况（非单身）、教育程度（低于高中）和不一致的安全套使用。总体而言，非CRF 01_AE菌株占感染的18.9%：男男性行为者占25.3%，异性恋女性和男性分别占14.8%和20.4%。我们的研究结果表明，在泰国男男性接触者中，艾滋病毒流行集中且遗传复杂。这些研究结果倡导在泰国的高风险人群中采取有针对性的干预和预防措施。
Several studies have reported an increasing number of non-CRF01_AE infections in high-risk groups in Thailand suggesting a more complex HIV-1 epidemic. This study assessed the complexity of the HIV epidemic among high-risk clients tested for HIV-1 at the Thai Red Cross Anonymous Clinic (TRCAC) between July 1, 2006 and February 28, 2007. HIV-1 genotypes were determined from plasma of infected subjects (n=401) by the multi-region hybridization assay (MHAbce, v. 2). Univariate and multivariate logistic regression analyses were used to determine risk factors associated with HIV prevalence and non-CRF01_AE infection. The estimated overall HIV prevalence was 14.1%: 25.3% among men who have sex with men (MSM), 18.4% among heterosexual women, and 9.6% among heterosexual men. Among the risk factors found to be associated with HIV prevalence were age (25-29 years), risk behavior (MSM), marital status (not single), education (less than high school), and inconsistent condom use. Overall, non-CRF01_AE strains accounted for 18.9% of the infections: 25.3% among MSM and 14.8% and 20.4% among heterosexual women and men, respectively. Our results indicate a concentrated and genetically complex HIV epidemic among Thai MSM. These findings advocate for targeted intervention and prevention measures among high-risk populations in Thailand.