LICK RATE ANALYSIS OF SODIUM TASTE-STATE COMBINATIONS
LICK RATE ANALYSIS OF SODIUM TASTE-STATE COMBINATIONS
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DOI：
10.1152/ajpregu.1993.264.2.r312
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发表时间：
1993-02-01
影响因子：
--
通讯作者：
GRILL, HJ
中科院分区：
文献类型：
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作者：
BRESLIN, PAS;KAPLAN, JM;GRILL, HJ
在两个实验中系统地评估了味觉和生理状态对 NaCl 舔率的综合影响。在实验 1 中，记录了 6 组大鼠 (Sprague-Dawley) 在 NaCl 饮用回合的前 3 分钟内的舔舐率，其中每组接受了不同的浓度。一半的大鼠通过注射利尿剂-利钠尿剂呋塞米（10 mg ip）而耗尽，而另一半则没有。钠充足大鼠的倒 U 形浓度反应函数大约在等渗时达到峰值。在钠耗尽状态下检查的大鼠的补充舔率函数一致升高。在实验 2 中，每只老鼠在 40 分钟的测试时间内获得了所有六种解决方案。对大鼠进行了两次测试，一次为正钠平衡，一次为负钠平衡。这些解决方案在一系列 10 秒的曝光中以平衡顺序重复呈现。组内研究的补充和耗尽功能与组间研究非常相似。当耗竭大鼠的功能被分为三个部分（与 40 分钟训练的开始、中间和结束一致）时，功能垂直向下移动，但保持其形状。一般来说，钠态水平显着影响绝对舔率，但似乎并未改变浓度响应函数沿水平（即浓度）轴的位置。该功能的形式似乎仅由口腔因素决定。
The combined effects of taste and physiological state on lick rate for NaCl were systematically evaluated in two experiments. In experiment 1 the lick rates of six groups of rats (Sprague-Dawley) were recorded during the first 3 min of a NaCl drinking bout, where each group received a different concentration. Half of the rats were depleted by injections of the diuretic-natriuretic furosemide (10 mg ip), whereas the other half were not. The inverted U-shaped concentration-response functions for sodium-replete rats peaked approximately at isotonicity. The replete lick rate function was uniformly elevated for rats examined in the sodium-depleted state. In experiment 2 each rat received access to all six solutions within a 40-min test session. Rats were tested twice, once in positive and once in negative sodium balance. The solutions were repeatedly presented in counterbalanced order in a series of 10-s exposures. The replete and deplete functions of the within-group study closely resembled those of the between-group study. When the deplete rats' function was divided into three segments coinciding with the beginning, middle, and end of the 40-min session, the functions were shifted down vertically but retained their shape. In general, sodium-state level dramatically affected the absolute lick rates but did not appear to shift the location of the concentration-response function along the horizontal (i.e., concentration) axis. The form of the function appears to have been determined by oral factors alone.