Identification of the Nukacin KQU-131, a New Type-A(II) Lantibiotic Produced by Staphylococcus hominis KQU-131 Isolated from Thai Fermented Fish Product (Pla-ra)
Identification of the Nukacin KQU-131, a New Type-A(II) Lantibiotic Produced by Staphylococcus hominis KQU-131 Isolated from Thai Fermented Fish Product (Pla-ra)
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DOI：
10.1271/bbb.80239
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发表时间：
2008-08
期刊：
影响因子：
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通讯作者：
P. Wilaipun;T. Zendo;Ken-ichi Okuda;J. Nakayama;K. Sonomoto
中科院分区：
文献类型：
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作者：
P. Wilaipun;T. Zendo;Ken-ichi Okuda;J. Nakayama;K. Sonomoto
人葡萄球菌（Staphylococcus hominis）KQU-131，分离自泰国发酵海鱼，产生一种热稳定细菌素。结构和遗传分析表明，细菌素是一种变异的nukacin ISK-1，A（II）型lantibiotic，我们称之为nukacin KQU-131。Nukacin ISK-1与Nukacin KQU-131的氨基酸序列有3个不同的氨基酸残基，1个在前导肽，2个在成熟肽。
Staphylococcus hominis KQU-131, isolated from Thai fermented marine fish, produces a heat stable bacteriocin. Structural and genetic analysis indicated that the bacteriocin is a variant of nukacin ISK-1, a type-A(II) lantibiotic, and we termed the bacteriocin nukacin KQU-131. There were three different amino acid residues between nukacin ISK-1 and nukacin KQU-131, one residue in the leader peptide and the other two in the mature peptide.