Epigenetic dynamics of the thermogenic gene program of adipocytes.
Epigenetic dynamics of the thermogenic gene program of adipocytes.
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DOI：
10.1042/bcj20190599
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发表时间：
2020-03-27
期刊：
影响因子：
--
通讯作者：
Sul HS
中科院分区：
文献类型：
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作者：
Yi D;Nguyen HP;Sul HS
棕色脂肪组织(BAT)是一种对新陈代谢有益的器官，能够将化学能转化为热量来燃烧脂肪，从而增加能量消耗。此外，皮下白色脂肪组织(WAT)可能会经历所谓的褐变/褐变。最近人们认识到成人中存在棕色或米色脂肪细胞，这引起了人们的极大关注，以阐明生热脂肪程序背后的分子机制。一些关键的转录调节因子对以激活UCP1启动子为中心的生热基因程序至关重要，已被发现。棕色脂肪细胞的致热基因表达依赖于多种转录因子的协同作用，包括Ebf2、PPARγ、Zfp516和Zc3H10。这些转录因子可能整合成一个BAT基因程序的内聚性网络。此外，这些转录因子招募表观遗传因子，如LSD1和MLL3/4，以获得特异组蛋白信号，以建立有利的染色质景观。在这篇综述中，我们讨论了在理解生热基因程序的分子机制方面所取得的进展，特别是表观遗传调控。
Brown adipose tissue (BAT) is a metabolically beneficial organ capable of burning fat by dissipating chemical energy into heat, thereby increasing energy expenditure. Moreover, subcutaneous white adipose tissue (WAT) can undergo so-called browning/beiging. The recent recognition of the presence of brown or beige adipocytes in human adults has attracted much attention to elucidate the molecular mechanism underlying the thermogenic adipose program. A number of key transcriptional regulators critical for the thermogenic gene program centering on activating the UCP1 promoter, have been discovered. Thermogenic gene expression in brown adipocytes rely on coordinated actions of a multitude of transcription factors, including EBF2, PPARγ, Zfp516 and Zc3h10. These transcription factors probably integrate into a cohesive network for BAT gene program. Moreover, these transcription factors recruit epigenetic factors, such as LSD1 and MLL3/4, for specific histone signatures to establish the favorable chromatin landscape. In this review, we discuss advances made in understanding the molecular mechanism underlying the thermogenic gene program, particularly epigenetic regulation.