Enhanced expression of AMPA receptor protein at perforated axospinous synapses
Enhanced expression of AMPA receptor protein at perforated axospinous synapses
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DOI：
10.1097/00001756-199803300-00017
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发表时间：
1998-03-30
期刊：
影响因子：
1.7
通讯作者：
Weinberg, RJ
中科院分区：
文献类型：
--
作者：
Desmond, NL;Weinberg, RJ
我们对大鼠齿状回分子层中间三分之一的区域进行了定量电镜分析，使用了谷氨酸受体亚基GluR1、GluR2/3或NMDAR1包埋后金标处理的材料。穿孔轴棘突触表达可检测水平的AMPA受体亚基的可能性至少是未穿孔轴棘突触的两倍，而NMDA受体的表达没有显著差异。这些数据表明穿孔突触可能特别有效，并且与AMPA受体蛋白插入先前沉默突触的突触后膜有助于长期增强的假设一致。(C) 1998快速科学有限公司
WE performed a quantitative electron microscopic analysis of the middle third of the molecular layer in the dentate gyrus of rat, using material processed with postembedding gold labeling for the glutamate receptor subunits GluR1, GluR2/3, or NMDAR1. Perforated axospinous synapses were at least twice as likely as nonperforated ones to express detectable levels of AMPA receptor subunits, whereas no significant differences in NMDA receptor expression were observed. These data imply that perforated synapses may be especially potent, and are consistent with the hypothesis that insertion of AMPA receptor protein into the postsynaptic membrane of previously silent synapses contributes to long-term potentiation. (C) 1998 Rapid Science Ltd.