Quality of life in survivors of hematological malignancies stratified by cancer type, time since diagnosis and stem cell transplantation
Quality of life in survivors of hematological malignancies stratified by cancer type, time since diagnosis and stem cell transplantation
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DOI：
10.1111/ejh.13104
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发表时间：
2018-09-01
影响因子：
3.1
通讯作者：
Goetze, Heide
中科院分区：
文献类型：
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作者：
Esser, Peter;Kuba, Katharina;Goetze, Heide
目的生命质量(Quality of Life，QOL)已成为指导肿瘤学决策的重要工具。然而，由于血液肿瘤幸存者之间的异质性，临床医生需要不同子集的比较数据。方法本研究从2个德国癌症登记中心招募血液恶性肿瘤幸存者(确诊后2.5年)。采用EORTC QLQ-C30进行生活质量评估。样本按癌症类型、确诊时间、干细胞移植(SCT)治疗和SCT类型进行分层。首先，在控制几个协变量的情况下，比较不同子样本的生活质量水平。其次，我们将亚样本与从普通人群中获得的性别和年龄匹配的人口对照进行对比。结果在通过邮件联系的2001名幸存者中，922人(46%)参与了研究。生活质量在不同的亚样本之间没有显著差异。与人群对照组相比，所有亚组样本的功能评分均显著降低，症状负担评分显著升高(均P
ObjectivesQuality of life (QoL) has become an important tool to guide decision making in oncology. Given the heterogeneity among hematological cancer survivors, however, clinicians need comparative data across different subsets.MethodsThis study recruited survivors of hematological malignancies (2.5years after diagnosis) from 2 German cancer registries. QoL was assessed with the EORTC QLQ-C30. The sample was stratified by cancer type, time since diagnosis, treatment with stem cell transplantation (SCT) and type of SCT. First, levels of QoL were compared across subsamples when controlling for several covariates. Second, we contrasted subsamples with gender- and age-matched population controls obtained from the general population.ResultsOf 2001 survivors contacted by mail, 922 (46%) participated in the study. QoL did not significantly differ between the subsamples. All subsamples scored significantly lower in functioning and significantly higher in symptom burden compared to population controls (all P