Reduced activity of the red-cell sodium-potassium pump in human obesity.
Reduced activity of the red-cell sodium-potassium pump in human obesity.
复制标题
人类肥胖症中红细胞钠钾泵的活性降低。
DOI：
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发表时间：
1980
影响因子：
158.5
通讯作者：
Jeffrey S. Flier
中科院分区：
文献类型：
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作者：
Mario De Luise;George L. Blackburn;Jeffrey S. Flier
为了寻找肥胖者细胞能量消耗减少的证据，我们测量了21名肥胖受试者红细胞中钠钾泵单位的数量，发现与非肥胖对照组相比，它们减少了22%（P <0.001）。阳离子转运活性的泵，作为测量由细胞吸收的86铷，我们也减少了平行减少泵单位。还发现肥胖受试者红细胞中钠浓度增加（每升细胞9.6 +/- 0.7对7.1 +/- 0.6 mmol; P<0.01）。这一发现独立地证明了钠泵单位数量减少和泵活性降低的生理重要性，分别通过哇巴因结合和铷转运来测量。发现泵单位数量减少的幅度与理想体重的百分比呈负相关（r = 0.56，P<0.001）;这一观察结果表明钠泵异常在肥胖的病理生理学中可能起作用。
Looking for evidence of reduced energy use in the cells of obese persons, we measured the numbers of sodium-potassium-pump units in erythrocytes from a group of 21 obese human subjects and found them to be reduced by 22 per cent as compared with those of nonobese controls (P <0.001). The cation-transport activity of the pump, as measured by 86rubidium uptake by the cells, we also reduced in parallel with decrease in pump units. An increased concentration of sodium in the red cells of obese subjectes was also found (9.6 +/- 0.7 vs. 7.1 +/- 0.6 mmol per liter of cells; P<0.01). This finding demonstrates independently the physiologic importance of reduced numbers of sodium-pump units and reduced pump activity as measured by ouabain binding and rubidium transport, respectively. The magnitude of the reduction in the number of pump units was found to be negatively correlated with the percentage of ideal body weight (r = 0.56, P<0.001); this observation suggests a possible role of abnormalities of the sodium pump in the pathophysiology of obesity.