Revisiting the Role of γδ T Cells in Anti-CMV Immune Response after Transplantation.
Revisiting the Role of γδ T Cells in Anti-CMV Immune Response after Transplantation.
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DOI：
10.3390/v13061031
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发表时间：
2021-05-29
期刊：
影响因子：
--
通讯作者：
Stikvoort A
中科院分区：
文献类型：
--
作者：
Gaballa A;Alagrafi F;Uhlin M;Stikvoort A
γ δ（γδ）T细胞形成T淋巴细胞的非常规亚群，表达由γ和δ链组成的T细胞受体（TCR）。与传统的αβ T细胞不同，γδ T细胞共享先天免疫和适应性免疫的免疫特征。这些特征使γδ T细胞能够在对抗感染和肿瘤的前线防御中发挥作用，使其成为免疫治疗的有吸引力的靶点。γδ T细胞在巨细胞病毒（CMV）免疫应答中的作用多年来一直是密集研究的焦点，特别是在移植的背景下，因为CMV再活化仍然是移植相关发病率和死亡率的主要原因。因此，更好地理解CMV免疫应答的机制可以设计新的基于γδ T细胞的治疗方法。在这方面，下一代测序（NGS）和单细胞TCR测序的出现允许深入表征CMV诱导的TCR库变化。在这篇综述中，我们试图阐明γδ T细胞在CMV免疫监视中的适应性作用的最新研究结果，并重新审视NGS时代CMV诱导的TCR重塑。最后，我们将证明移植后CMV反应性γδ T细胞的有利和不利作用。
Gamma delta (γδ) T cells form an unconventional subset of T lymphocytes that express a T cell receptor (TCR) consisting of γ and δ chains. Unlike conventional αβ T cells, γδ T cells share the immune signature of both the innate and the adaptive immunity. These features allow γδ T cells to act in front-line defense against infections and tumors, rendering them an attractive target for immunotherapy. The role of γδ T cells in the immune response to cytomegalovirus (CMV) has been the focus of intense research for several years, particularly in the context of transplantation, as CMV reactivation remains a major cause of transplant-related morbidity and mortality. Therefore, a better understanding of the mechanisms that underlie CMV immune responses could enable the design of novel γδ T cell-based therapeutic approaches. In this regard, the advent of next-generation sequencing (NGS) and single-cell TCR sequencing have allowed in-depth characterization of CMV-induced TCR repertoire changes. In this review, we try to shed light on recent findings addressing the adaptive role of γδ T cells in CMV immunosurveillance and revisit CMV-induced TCR reshaping in the era of NGS. Finally, we will demonstrate the favorable and unfavorable effects of CMV reactive γδ T cells post-transplantation.
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影响因子：
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作者：
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