Inside job: Staphylococcus aureus host-pathogen interactions
Inside job: Staphylococcus aureus host-pathogen interactions
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DOI：
10.1016/j.ijmm.2017.11.009
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发表时间：
2018-08-01
影响因子：
4.1
通讯作者：
Fraunholz, Martin
中科院分区：
文献类型：
--
作者：
Horn, Jessica;Stelzner, Kathrin;Fraunholz, Martin
金黄色葡萄球菌（Staphylococcus aureus）是一种臭名昭著的机会致病菌，可引起多种疾病。最近的研究表明，一旦被中性粒细胞和巨噬细胞吞噬，一定比例的S。金黄色葡萄球菌能够在这些吞噬细胞内存活，从而甚至可能有助于病原体的传播。S.金黄色葡萄球菌进一步诱导其被其他非吞噬细胞摄取，并且随后的细胞内细胞毒性被认为导致组织破坏，而细胞内的细菌持久性被认为导致免疫逃避和感染的慢性化。我们在这里回顾最近的工作S。金黄色葡萄球菌宿主病原体相互作用，重点是病原体的细胞内存活。
Staphylococcus aureus is a notorious opportunistic pathogen causing a plethora of diseases. Recent research established that once phagocytosed by neutrophils and macrophages, a certain percentage of S. aureus is able to survive within these phagocytes which thereby even may contribute to dissemination of the pathogen. S. aureus further induces its uptake by otherwise non-phagocytic cells and the ensuing intracellular cytotoxicity is suggested to lead to tissue destruction, whereas bacterial persistence within cells is thought to lead to immune evasion and chronicity of infections. We here review recent work on the S. aureus host pathogen interactions with a focus on the intracellular survival of the pathogen.