SOCIAL-STATUS AND NERVE GROWTH-FACTOR SERUM LEVELS AFTER AGONISTIC ENCOUNTERS IN MICE
SOCIAL-STATUS AND NERVE GROWTH-FACTOR SERUM LEVELS AFTER AGONISTIC ENCOUNTERS IN MICE
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DOI：
10.1016/0031-9384(90)90056-a
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发表时间：
1990-01-01
影响因子：
2.9
通讯作者：
ALLEVA, E
中科院分区：
文献类型：
--
作者：
MAESTRIPIERI, D;DESIMONE, R;ALLEVA, E
对同一对被隔离的雄性小鼠进行10次重复的每日互动（每次20分钟），可以明显区分攻击（优势）和被击败（从属）的动物。战斗水平在10天内保持相当稳定。在第10次实验结束1小时后，先前(2)描述的血清NGF水平的增加在从属小鼠中比在优势小鼠中更为明显。血清NGF的平均水平与打斗次数相关，特别是在优势个体中。此外，NGF值的对内差异与支配和从属之间的运动活动差异相关；这使得除了战斗本身产生的刺激外，其他刺激可能是导致循环NGF增加的原因。众所周知，对抗压力所产生的肾上腺肥大在从属小鼠中比在优势小鼠中更为明显，而先前的研究表明，非社会心理类型的压力不会提高血清NGF水平。因此，目前的数据支持这一假设，即NGF的释放有助于以特定情况的方式调节肾上腺功能。
Ten repeated daily interactions (20 min each) of the same pairs of isolated male mice produced a clear distinction between attacking (dominant) and defeated (subordinate) animals. The fighting level remained fairly constant over the 10 days. One hr after the end of the 10th session, the increase in serum NGF levels described previously (2) was significantly more marked in subordinate than in dominant mice. The mean level of serum NGF was correlated with the number of fighting episodes, particularly in the case of dominant individuals. Moreover, within-pair differences in NGF values were correlated with differences in locomotor activity between dominants and subordinates; this makes it possible that stimuli other than those produced by fighting per se may be responsible for the increase in circulating NGF. As is well known, the adrenal hypertrophy produced by fighting stress is more marked in subordinate than in dominant mice, while previous work has shown that stress of a nonpsychosocial kind does not elevate serum NGF levels. Therefore, the present data support the hypothesis that NGF release contributes to the modulation of adrenal function in a situation-specific fashion.