Stable Encoding of Visual Cues in the Mouse Retrosplenial Cortex.
Stable Encoding of Visual Cues in the Mouse Retrosplenial Cortex.
复制标题
小鼠压后皮层视觉线索的稳定编码。
DOI：
10.1093/cercor/bhaa030
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Powell A
中科院分区：
文献类型：
--
作者：
Powell A
啮齿类动物的压后皮质（RSC）是感觉和运动信号的整合中心，在导航和记忆中发挥作用。虽然RSC与感觉皮层紧密相连，但感觉信息在RSC中的表现形式以及它如何与运动反馈相互作用尚不清楚，可能对导航（如路径整合）中的计算至关重要。在这里，我们使用2-光子细胞成像的神经活动的假定兴奋性（CaMKII表达）和抑制性（小白蛋白表达）神经元，以测量视觉和运动诱发的活动在RSC和比较它的初级视觉皮层（V1）。我们观察到刺激的位置和方向调整，和视网膜组织。运动调制的单个神经元的活动，无论是在黑暗和光明中，是更明显的RSC比V1，而运动调制是最强的RSC小白蛋白阳性神经元，视觉运动的整合被发现是更supralinear在CaMK II神经元。纵向测量结果表明，响应特性稳定地保持了许多周。这些数据提供了证据的稳定表示的视觉线索在RSC的空间选择性。这些可以提供感官数据，有助于形成空间信息的记忆。
The rodent retrosplenial cortex (RSC) functions as an integrative hub for sensory and motor signals, serving roles in both navigation and memory. While RSC is reciprocally connected with the sensory cortex, the form in which sensory information is represented in the RSC and how it interacts with motor feedback is unclear and likely to be critical to computations involved in navigation such as path integration. Here, we used 2-photon cellular imaging of neural activity of putative excitatory (CaMKII expressing) and inhibitory (parvalbumin expressing) neurons to measure visual and locomotion evoked activity in RSC and compare it to primary visual cortex (V1). We observed stimulus position and orientation tuning, and a retinotopic organization. Locomotion modulation of activity of single neurons, both in darkness and light, was more pronounced in RSC than V1, and while locomotion modulation was strongest in RSC parvalbumin-positive neurons, visual-locomotion integration was found to be more supralinear in CaMKII neurons. Longitudinal measurements showed that response properties were stably maintained over many weeks. These data provide evidence for stable representations of visual cues in RSC that are spatially selective. These may provide sensory data to contribute to the formation of memories of spatial information.