Role and Cost Effectiveness of PET/CT in Management of Patients with Cancer
Role and Cost Effectiveness of PET/CT in Management of Patients with Cancer
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发表时间：
2010-06
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通讯作者：
M. Saif;I. Tzannou;N. Makrilia;K. Syrigos
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作者：
M. Saif;I. Tzannou;N. Makrilia;K. Syrigos
PET/CT是一种较新的成像技术，其无可置疑的优势在临床肿瘤学以及诊断、分期和治疗的各个领域都具有重要的价值。解剖和功能的硬件结合是成像的真正演变。使用18F-脱氧葡萄糖(FDG)的PET越来越多地用于实体肿瘤的分期，包括结肠、肺等，但解剖学信息有限。综合的PET/CT能够在CT图像上对PET表现和FDG阴性病变进行最佳的解剖描述，并可能改善术前分期。然而，关于PET/CT在临床上的应用仍然存在争议，主要是因为它的成本很高。显然，除了额外的成本外，由于避免了额外的成像检查或侵入性程序，并通过帮助临床医生做出最佳治疗决策，PET/CT还可能节省成本。作者回顾了关于PET/CT在各种肿瘤治疗中的作用的文献，并讨论了其医学经济学的用处。
PET/CT is a relatively new imaging technology, whose undoubted advantages are valuable in clinical oncology as well as in all fields of diagnosis, staging, and treatment. The hardware combination of anatomy and function has been the true evolution in imaging. PET using 18F-fluorodeoxyglucose (FDG) is increasingly used for the staging of solid malignancies, including colon, lung, etc., but anatomic information is limited. Integrated PET/CT enables optimal anatomic delineation of PET findings and identification of FDG-negative lesions on computed tomography (CT) images and might improve preoperative staging. However, controversy still exists in relation to the application of PET/CT in clinical practice, mainly because of its high cost. It is evident that apart from additional costs, potential savings also are associated with PET/CT as a result of avoiding additional imaging examinations or invasive procedures and by helping clinicians make the optimum treatment decisions. The authors review the literature on the role of PET/CT in management of various tumors and discuss the medicoeconomic usefulness.