CALHM1 P86L Polymorphism is a Risk Factor for Alzheimer's Disease in the Chinese Population
CALHM1 P86L Polymorphism is a Risk Factor for Alzheimer's Disease in the Chinese Population
复制标题
DOI：
10.3233/jad-2010-1207
复制
发表时间：
2010-01-01
影响因子：
4
通讯作者：
Chen, Sheng-Di
中科院分区：
文献类型：
--
作者：
Cui, Pei-Jing;Zheng, Lan;Chen, Sheng-Di
我们进行了一项病例对照研究，以确定中国大陆人群中阿尔茨海默病（AD）患者中CALHM 1 P86 L多态性（rs 2986017）的患病率，并阐明该多态性是否是AD的危险因素。在198例AD患者中发现14例P86 L杂合子携带者。还发现一名对照受试者是P86 L杂合携带者。AD患者和对照组的等位基因频率有显著性差异。我们的研究表明，CALHM 1-P86 L多态性与中国汉族AD相关。
We conducted a case-control study to determine the prevalence of the CALHM1 P86L polymorphism (rs2986017) in patients with Alzheimer's disease (AD) in the Chinese population of mainland China, and also to clarify whether this polymorphism is a risk factor for AD. Fourteen heterozygous P86L carriers were identified among 198 AD patients. One control subject was also found to be a P86L heterozygous carrier. The allelic frequencies of the AD patients and control subjects were found to be significantly different. Our study indicates that the CALHM1-P86L polymorphism is associated with AD in the ethnic Chinese Han.