Exploiting Endocytosis for Nanomedicines
Exploiting Endocytosis for Nanomedicines
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DOI：
10.1101/cshperspect.a016980
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发表时间：
2013-11-01
影响因子：
7.2
通讯作者：
Battaglia, Giuseppe
中科院分区：
文献类型：
--
作者：
Akinc, Akin;Battaglia, Giuseppe
在本文中，我们简要回顾了细胞使用的内吞途径，指出了它们的定义特征并强调了可能将纳米颗粒内化到这些途径的子集的物理限制。文献中对这些途径有更详细的描述。然后，我们重点关注纳米药物的内吞作用，并介绍各种纳米材料参数如何影响这些内吞过程。该主题是一个活跃的研究领域，其动机是认识到提高对纳米材料如何在分子、细胞和整个有机体水平上相互作用的理解将有助于在未来设计出更好的纳米药物。接下来，我们简要回顾一些已经上市或处于临床开发阶段的重要纳米药物，这些纳米药物可以举例说明如何利用内吞作用来获得医疗益处。最后，我们提出了一些尚未解答的关键问题以及该领域需要解决的剩余挑战。
In this article, we briefly review the endocytic pathways used by cells, pointing out their defining characteristics and highlighting physical limitations that may direct the internalization of nanoparticles to a subset of these pathways. A more detailed description of these pathways is presented in the literature. We then focus on the endocytosis of nanomedicines and present how various nanomaterial parameters impact these endocytic processes. This topic is an area of active research, motivated by the recognition that an improved understanding of how nanomaterials interact at the molecular, cellular, and whole-organism level will lead to the design of better nanomedicines in the future. Next, we briefly review some of the important nanomedicines already on the market or in clinical development that serve to exemplify how endocytosis can be exploited for medical benefit. Finally, we present some key unanswered questions and remaining challenges to be addressed by the field.