The Loxtox protein family in Loxosceles intermedia (Mello-Leit(a)over-tildeo) venom
The Loxtox protein family in Loxosceles intermedia (Mello-Leit(a)over-tildeo) venom
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DOI：
10.1016/j.toxicon.2007.07.001
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发表时间：
2007-12-01
期刊：
影响因子：
2.8
通讯作者：
Barbaro, K. C.
中科院分区：
文献类型：
--
作者：
Kalapothakis, E.;Chatzaki, M.;Barbaro, K. C.
我们分离的cDNA序列编码皮肤坏死/鞘磷脂酶因子蛋白质的棕色蜘蛛Loxosceles intermedia，这里命名为Loxtox蛋白。几个Loxtox蛋白的cDNA克隆的基础上的氨基酸序列揭示了至少六个不同的蛋白质组中表达的毒腺。毒素之间的相似性水平从99%到55%不等。在这种蜘蛛的毒液中发现几种Loxtox亚型可能反映了对不同猎物类型的进化适应，并加强了蜘蛛毒腺中有效突变机制的想法。(c)2007爱思唯尔有限公司保留所有权利。
We isolated cDNA sequences coding for dermonecrotic/sphingomyelinases factor proteins from the brown spider Loxosceles intermedia, here named Loxtox proteins. The amino acid sequences based on cloned cDNA of several Loxtox proteins revealed at least six distinct groups of proteins expressed in the venom gland. The level of similarity among the toxins varied from 99% to 55%. The finding of several isoforms of Loxtox in the venom of this spider may reflect an evolutionary adaptation for different prey types and reinforces the idea of an efficient mutational mechanism in the venom gland of spiders. (c) 2007 Elsevier Ltd. All rights reserved.