Cytoskeletal mechanisms for platelet production
Cytoskeletal mechanisms for platelet production
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DOI：
10.1016/j.bcmd.2005.12.007
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发表时间：
2006-03-01
影响因子：
2.3
通讯作者：
Italiano, JE
中科院分区：
文献类型：
--
作者：
Hartwig, JH;Italiano, JE
主要生活在骨髓间隙的巨核细胞释放血小板。血小板形成的中间体是前血小板，这是一种长管状过程，通过基于微管的力从巨核细胞体延伸数百微米。颗粒和细胞器进入前血小板，并在其微管上上下移动，最终在释放前输送到血小板芽。个体血小板如何形成和从前血小板释放仍然知之甚少。(c)2006年爱思唯尔公司All rights reserved.
Platelets release from megakaryocytes living primarily in the bone marrow space. Intermediates in platelet formation are proplatelets, long tube-like processes that are extended by microtubule-based forces hundreds of micrometers from the megakaryocyte cell body. Granules and organelles enter the proplatelets and traffic up and down on their microtubules to be ultimately delivered to the platelet buds before they release. How individual platelets form and release from proplatelets remains poorly understood. (c) 2006 Elsevier Inc. All rights reserved.