Magnetic resonance spectroscopy of the thalamus in patients with typical absence epilepsy
Magnetic resonance spectroscopy of the thalamus in patients with typical absence epilepsy
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DOI：
10.1016/j.seizure.2006.06.007
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发表时间：
2006-10-01
影响因子：
3
通讯作者：
Rektor, Ivan
中科院分区：
文献类型：
--
作者：
Fojtikova, Dagmar;Brazdil, Milan;Rektor, Ivan
目的：应用磁共振波谱（MRS）研究典型失神癫痫患者丘脑可能的神经元功能障碍。特别注意N-乙酰天冬氨酸（NAA）和肌酸（Cr）的水平，和NAA/Cr ratio.Methods：MRS进行了超过右，左丘脑9例患有典型的失神癫痫，并在9个性别和年龄匹配的健康，对照。所有患者和对照组进行了检查，使用一个标准的MRS CSI（化学位移成像）techniques.Results：所获得的数据的统计分析表明，一个显着较低的丘脑NAA/Cr比值在典型的失神癫痫患者相比，健康对照组。结果表明，患者组和正常对照组的NAA/Cr比值在左右丘脑呈对称性分布。患者的丘脑NAA/Cr值和癫痫发作的持续时间或发作频率之间没有显着的相关性revealed.Conclusions：目前的MRS数据清楚地表明，在典型的失神癫痫患者的丘脑神经元功能障碍。在协议与其他最近的MRS结果在不同的特发性全身性癫痫综合征，我们的研究结果证实了丘脑的作用，作为一个重要的结构，在典型的失神癫痫的发病机制。(C)2006年英国癫痫协会。由爱思唯尔有限公司出版。保留所有权利。
Purpose: To investigate possible neuronal dysfunction of the thalamus in patients suffering from typical absence epilepsy, using magnetic resonance spectroscopy (MRS). Special attention was paid to levels of N-acetylaspartate (NAA) and creatine (Cr), and to the NAA/Cr ratio.Methods: MRS was performed over the right and left thalamus in nine patients suffering from typical absence epilepsy, and in nine sex- and age-matched healthy, controls. All patients and controls were examined using a standard MRS-CSI (chemical shift imaging) technique.Results: Statistical analysis of the obtained data demonstrated a significantly Lower thalamic NAA/Cr ratio in patients with typical absence epilepsy when compared to the healthy controls. Our MRS data showed symmetrical distribution of NAA/Cr ratio in the right and left thalamus within both the patient group and the group of healthy controls. No significant correlation between the patients' thalamic NAA/Cr values and the duration of the epilepsy or seizure frequency was revealed.Conclusions: The present MRS data clearly indicate neuronal dysfunction in the thalami of patients with typical absence epilepsy. In agreement with other recent MRS findings in different idiopathic generalized epilepsy syndromes, our results confirm the role of the thalamus as an important structure in the pathogenesis of typical absence epilepsy. (C) 2006 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.