Liver damage after halothane anaesthesia: analysis of cases in Finnish hospitals in 1972-1981.
Liver damage after halothane anaesthesia: analysis of cases in Finnish hospitals in 1972-1981.
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氟烷麻醉后肝损伤：1972-1981 年芬兰医院病例分析。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
P. Rosenberg
中科院分区：
文献类型：
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作者：
M. Oikkonen;P. Rosenberg
回顾性问卷调查显示芬兰1972-1981年间11例氟烷相关肝脏紊乱。7例被认为是明显的，2例被认为是可能的氟烷肝炎（HH）。4例患者两次发生HH，没有一例有致命的结果。黄疸发作的速度与氟烷暴露的次数有关，肝酶（ASAT， ALAT）活性的增加和血清胆红素浓度的增加也是如此。如果先前接触过氟烷后出现不明黄疸，则严格禁止使用氟烷麻醉。如果先前接触后出现明显发热或持续恶心，则不应给予本品。没有发现与安氟醚有关的重大不良反应或器官毒性。
A retrospective questionnaire revealed 11 patients with halothane related liver disturbances in Finland in 1972-1981. Seven of the cases were regarded as obvious and two as probable halothane hepatitis (HH). Four patients suffered HH twice, and none of the cases had a fatal outcome. The speed of onset of icterus correlated with the number of halothane exposures, as did the increase in liver enzyme (ASAT, ALAT) activities and the increase in serum bilirubin concentration. Halothane anaesthesia is strictly contraindicated if a nondefinite icterus has appeared after a previous exposure to halothane. It should not be given if unclear fever or prolonged nausea have followed a previous exposure. No major adverse effects or organ toxicity connected with enflurane were found.