Decoupled LIGHT-SABRE variants allow hyperpolarization of asymmetric SABRE systems at an arbitrary field
Decoupled LIGHT-SABRE variants allow hyperpolarization of asymmetric SABRE systems at an arbitrary field
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DOI：
10.1016/j.jmr.2019.106577
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发表时间：
2019-10-01
影响因子：
2.2
通讯作者：
Warren, Warren S.
中科院分区：
文献类型：
--
作者：
Lindale, Jacob R.;Tanner, Christian P. N.;Warren, Warren S.
通过可逆交换的信号放大，或SABRE，使用仲氢的单线态顺序在靶核上产生超极化信号，绕过传统磁共振的限制。直接在磁体中进行的实验提供了一种连续产生大磁化的途径，而不必对样品进行场循环。对于杂原子SABRE，这些高场方法已被限制到少数SABRE配合物，表现出有效的交换与对称的配体环境作为共配体诱导仲氢衍生的杂原子之间的化学位移差异，破坏超极化的自旋顺序。通过仔细考虑潜在的自旋物理，我们引入了H-1解耦的LIGHT-SABRE脉冲序列变体，绕过了这一限制，大大扩展了高场异质结SABRE的范围。(C)2019爱思唯尔公司All rights reserved.
Signal Amplification By Reversible Exchange, or SABRE, uses the singlet-order of parahydrogen to generate hyperpolarized signals on target nuclei, bypassing the limitations of traditional magnetic resonance. Experiments performed directly in the magnet provide a route to generate large magnetizations continuously without having to field-cycle the sample. For heteronuclear SABRE, these high-field methods have been restricted to the few SABRE complexes that exhibit efficient exchange with symmetric ligand environments as co-ligands induce chemical shift differences between the parahydrogen-derived hydrides, destroying the hyperpolarized spin order. Through careful consideration of the underlying spin physics, we introduce H-1 decoupled LIGHT-SABRE pulse sequence variants which bypasses this limitation, drastically expanding the scope of heteronuclear SABRE at high field. (C) 2019 Elsevier Inc. All rights reserved.