High expressions of vascular endothelial growth factor and platelet-derived endothelial cell growth factor predict poor prognosis in alpha-fetoprotein-negative hepatocellular carcinoma patients after curative resection
High expressions of vascular endothelial growth factor and platelet-derived endothelial cell growth factor predict poor prognosis in alpha-fetoprotein-negative hepatocellular carcinoma patients after curative resection
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DOI：
10.1007/s00432-009-0577-5
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发表时间：
2009-10-01
影响因子：
3.6
通讯作者：
Zhou, Jian
中科院分区：
文献类型：
--
作者：
Hu, Jie;Xu, Yang;Zhou, Jian
为探讨血管内皮生长因子（VEGF）和血小板源性内皮细胞生长因子（PD-ECGF）在甲胎蛋白（AFP）阴性肝癌（HCC）患者术后预后判断中的价值，应用肿瘤组织芯片（TMAs）检测162例AFP阴性HCC患者术后VEGF和PD-ECGF的表达，并与正常肝组织比较。1997年至2000年间，我院收治了10例肝癌根治性切除术后阴性的患者。对这些患者的临床病理资料进行了评价。使用Kaplan-Meier生存估计和对数秩检验评估预后意义。多因素分析采用考克斯比例风险模型，VEGF和PD-ECGF在162例胃癌组织中的阳性表达率分别为59.9%（97/162）和62.3%（101/162）。单因素分析显示VEGF和PD-ECGF是无复发生存期的预后因素（分别为P = 0.034和P = 0.033）。多因素分析显示，VEGF/PD-ECGF联合指标是影响总生存率和无复发生存率的独立预后因素（P = 0.002和P = 0.000），VEGF和PD-ECGF联合指标是预测AFP阴性肝癌患者术后复发和生存的独立预测指标。
To evaluate the prognosis value of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) in alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) patients after curative resection.Tumor tissue microarrays (TMAs) were used to detect the expressions of VEGF and PD-ECGF in consecutive 162 AFP-negative HCC patients undergoing curative resection between 1997 and 2000 in our institute. Clinicopathologic data for these patients were evaluated. The prognostic significance was assessed using Kaplan-Meier survival estimates and log-rank tests. Multivariate study with Cox's proportional hazard model was used to evaluate the prognosis-related aspects.The positive rates of VEGF and PD-ECGF in tumor tissues were 59.9% (97/162) and 62.3% (101/162), respectively. Univariate analysis showed that VEGF and PD-ECGF were prognostic factors for relapse-free survival (P = 0.034 and P = 0.033, respectively). Multivariate analyses demonstrated that the co-index (VEGF/PD-ECGF) was an independent prognostic factor for overall survival and relapse-free survival (P = 0.002 and P = 0.000, respectively).The co-index of VEGF and PD-ECGF is a promising independent predictor for recurrence and survival of AFP-negative HCC patients after curative resection.