The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys
The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys
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DOI：
10.1016/s0197-4580(96)00162-5
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发表时间：
1997-01-01
影响因子：
4.2
通讯作者：
Stanhope, KJ
中科院分区：
文献类型：
--
作者：
Arnsten, AFT;Lin, CH;Stanhope, KJ
5-羟色胺5-HT 3受体拮抗剂昂丹司琼和SEC-579在老年恒河猴中在宽剂量范围（0.000001-0.5 mg/kg，PO）内测试认知增强作用。对动物进行以下认知和运动任务测试：1）获得视觉对象辨别; 2）视觉对象辨别的逆转; 3）延迟响应任务，空间工作记忆任务;和4）精细运动任务。本研究发现，在极低剂量（0.000001-0.00001 mg/kg，PO）的任一5-HT 3受体拮抗剂后，视觉障碍辨别的获得增强。这一发现重复了先前在绒猴中的研究（14）。然而，与绒猴研究不同的是，在逆转条件下没有发现可靠的改善。同样，在延迟反应或精细运动任务上也没有观察到改善。在任何剂量下均未观察到副作用。与动物和人类的报告一致。这些结果表明，5-HT 3受体拮抗剂可能有助于治疗认知功能的子集。版权所有（C）1996 Elsevier Science Inc.
The serotonin 5-HT3 receptor antagonists ondansetron and SEC-579 were tested over a wide dose range (0.000001-0.5 mg/kg, PO) for cognitive-enhancing effects in aged rhesus monkeys. Animals were tested on the following cognitive and motor tasks: 1) acquisition of a visual object discrimination; 2) reversal of a visual object discrimination; 3) the delayed response task, a spatial working memory task; and 4) a fine motor task. This study found enhanced acquisition of a visual abject discrimination following very low doses (0.000001-0.00001 mg/kg, PO) of either 5-HT3 receptor antagonist. This finding replicates a previous study in marmosets (14). However, unlike the marmoset research, no reliable improvement was found on the reversal condition. Similarly, no improvement was observed on the delayed response or fine motor tasks. No side effects were observed at any dose. consistent with reports in both animals and humans. These results suggest that 5-HT3 receptor antagonists may be helpful in treating a subset of cognitive functions. Copyright (C) 1996 Elsevier Science Inc.