Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets.
Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets.
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DOI：
10.3177/jnsv.63.237
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发表时间：
2017
影响因子：
1.6
通讯作者：
Fang-Hang Zhou;X. Deng;Yan-qiu Chen;Fuli Ya;Xiandan Zhang;F. Song;Dan Li;Yan Yang
中科院分区：
文献类型：
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作者：
Fang-Hang Zhou;X. Deng;Yan-qiu Chen;Fuli Ya;Xiandan Zhang;F. Song;Dan Li;Yan Yang
血小板颗粒释放被认为是预防和治疗心血管疾病（CVD）的重要靶点。矢车菊素-3-葡萄糖苷（Cyanidin-3-glucoside，Cy-3-g）是许多可食用植物中的主要生物活性花色素苷化合物，并已报道通过减轻血小板功能障碍来保护免受CVD。然而，直接证据的行动，Cy-3-g对血小板颗粒分泌纯化血小板在体内试验仍然是穷人。在本研究中，我们证明，膳食补充纯化的Cy-3-g降低血清脂质水平，并促进下调血小板颗粒释放的物质，如P-选择素，CD 40 L，5-HT，RANTES和TGF-β1在凝胶过滤的血小板，除了降低高脂饮食小鼠的血清PF 4和β-TG水平。这些结果提供了Cy-3-g通过抑制体内纯化的血小板颗粒释放来防止血栓形成和CVD的证据。
Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD40L, 5-HT, RANTES and TGF-β1 in gel-filtered platelets, in addition to attenuating serum PF4 and β-TG levels in mice fed high-fat diets. These results provide evidence that Cy-3-g protects against thrombosis and CVDs by inhibiting purified platelet granule release in vivo.