Engineering the Structure and Rheological Properties of P407 Hydrogels via Reverse Poloxamer Addition.
Engineering the Structure and Rheological Properties of P407 Hydrogels via Reverse Poloxamer Addition.
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DOI：
10.1021/acs.langmuir.3c00088
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发表时间：
2023-03
期刊：
影响因子：
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通讯作者：
Joan D. M. White;Ally Garza;James J. Griebler;F. Bates;M. Calabrese
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文献类型：
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作者：
Joan D. M. White;Ally Garza;James J. Griebler;F. Bates;M. Calabrese
poloxam407 （P407）的水溶液是一种市售的无毒的ABA三段聚合物（PEO-PPO-PEO），随着温度的升高，溶液向凝胶转变，是注射治疗的有希望的候选者。凝胶转变温度、模量和结构都是由聚合物浓度决定的，从而阻止了这些特性的独立调整。在这里，我们证明了在p407基溶液中加入BAB反向poloxomer （rp）会显著改变凝胶温度、模量和形貌。凝胶温度和RP在水凝胶中的定位取决于RP的溶解度。高可溶性RPs提高凝胶温度，并主要并入胶束电晕区。另外，具有低水溶性的RPs降低了凝胶温度，并在胶束核心和核心-电晕界面内结合。这些RP定位的差异对水凝胶模量和微观结构具有重要意义。通过添加RP调整凝胶温度、模量和结构的能力允许设计具有特定性能的热敏材料，这些性能是纯p407基水凝胶无法获得的。
Aqueous solutions of poloxamer 407 (P407), a commercially available and nontoxic ABA triblock polymer (PEO-PPO-PEO), undergo a solution-to-gel transition with increasing temperature and are promising candidates for injectable therapeutics. The gel transition temperature, modulus, and structure are all dictated by polymer concentration, preventing independent tuning of these properties. Here, we show that addition of BAB reverse poloxamers (RPs) to P407-based solutions dramatically alters the gelation temperature, modulus, and morphology. Gelation temperature and RP localization within the hydrogel are dictated by RP solubility. Highly soluble RPs increase gelation temperature and incorporate primarily into the micelle corona regions. Alternatively, RPs with low aqueous solubility decrease gelation temperature and associate within the micelle core and core-corona interface. These differences in RP localization have significant implications for the hydrogel modulus and microstructure. The ability to tune gelation temperature, modulus, and structure through RP addition allows for the design of thermoresponsive materials with specific properties that are unobtainable with neat P407-based hydrogels.