Perfect ALKemy: optimizing the use of ALK-directed therapies in lung cancer.
Perfect ALKemy: optimizing the use of ALK-directed therapies in lung cancer.
复制标题
Perfect ALKemy:优化 ALK 导向疗法在肺癌中的使用。
DOI:
10.1158/1078-0432.ccr-14-2306
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发表时间:
2014
期刊:
影响因子:
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通讯作者:
Gettinger,Scott
中科院分区:
文献类型:
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作者:
Politi,Katerina;Gettinger,Scott
Mutations in ALK are a common mechanism of acquired resistance to small molecule ALK inhibitors in ALK-rearranged lung cancer. Different mutants exhibit differential sensitivity to ALK inhibitors. Matching the mutational profile of the tumor with the appropriate ALK inhibitor is likely to be important to maximize benefit for patients.Clin Cancer Res; 20(22); 5576–8. ©2014 AACR.