Salience network connectivity in the insula is associated with individual differences in interoceptive accuracy
Salience network connectivity in the insula is associated with individual differences in interoceptive accuracy
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DOI：
10.1007/s00429-016-1297-7
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发表时间：
2017-05-01
影响因子：
3.1
通讯作者：
Zhou, Juan
中科院分区：
文献类型：
--
作者：
Chong, Joanna Su Xian;Ng, Gavin Jun Peng;Zhou, Juan
前扣带皮层和前扣带皮层是大脑的核心区域，锚的显着性网络，其中一个大规模的内在功能连接网络，已得到一致的使用静息态功能磁共振成像（fMRI）。虽然有几项研究表明，大脑皮层和前扣带皮层在内感受性意识中起着重要作用，但迄今为止还没有研究探讨内在显着性网络连接和内感受性意识之间的关系。在这项研究中，我们试图在26名健康的年轻参与者中测试这一想法，这些参与者在同一个阶段接受了静息状态fMRI扫描和扫描仪外的心跳计数任务。使用独立成分分析的后扣带皮层（而不是前扣带皮层）中更大的显着网络连接与心跳计数任务的更高准确性相关。此外，使用基于种子的方法，更大的内感受准确性与所有岛屿功能分区到显着网络区域（包括前额叶，眶额皮质，腹侧纹状体和中脑）的更大内在连接性相关。这些关联在校正体素灰质体积后仍然存在。这些发现强调了岛屿显着网络内在连接在内感受性意识中的关键作用，并为未来研究显着网络连接障碍如何影响大脑疾病的内感受性意识铺平了道路。
The insula and the anterior cingulate cortex are core brain regions that anchor the salience network, one of several large-scale intrinsic functional connectivity networks that have been derived consistently using resting-state functional magnetic resonance imaging (fMRI). While several studies have shown that the insula and anterior cingulate cortex play important roles in interoceptive awareness, no study to date has examined the association between intrinsic salience network connectivity and interoceptive awareness. In this study, we sought to test this idea in 26 healthy young participants who underwent a resting-state fMRI scan and a heartbeat counting task outside the scanner in the same session. Greater salience network connectivity in the posterior insula (but not the anterior cingulate cortex) using independent component analysis correlated with higher accuracy in the heartbeat counting task. Furthermore, using seed-based approach, greater interoceptive accuracy was associated with greater intrinsic connectivity of all insular functional subdivisions to salience network regions, including the anterior insula, orbitofrontal cortex, ventral striatum and midbrain. These associations remained after correcting for voxel-wise grey matter volumes. The findings underscore the critical role of insular salience network intrinsic connectivity in interoceptive awareness and pave the way for future investigations into how salience network dysconnectivity affects interoceptive awareness in brain disorders.