Involvement of B cells in non-infectious uveitis.
Involvement of B cells in non-infectious uveitis.
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DOI：
10.1038/cti.2016.2
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发表时间：
2016-02
影响因子：
5.8
通讯作者：
Appukuttan B
中科院分区：
文献类型：
--
作者：
Smith JR;Stempel AJ;Bharadwaj A;Appukuttan B
非感染性葡萄膜炎-或眼内炎性疾病-在受影响的个体中引起严重的视力发病率和生活质量下降。迄今为止，致病机制的研究主要集中在涉及T淋巴细胞和/或髓系白细胞群的过程上。B淋巴细胞的参与受到的关注相对较少。相比之下，B细胞病理生物学是普通免疫学研究的一个主要领域，大型临床试验表明，针对B细胞的治疗对多种全身性炎症疾病非常有效。B细胞，包括产生抗体的终末分化浆细胞，存在于人眼不同形式的非感染性葡萄膜炎中；在某些情况下，这些细胞的数量超过其他白细胞亚群。最近的病例报告和小病例系列表明，b细胞阻断可能对非感染性葡萄膜炎患者有治疗作用。除了分泌抗体外，B细胞还可能通过向T细胞呈递抗原、产生多种炎症细胞因子和支持T细胞存活来促进眼内炎症。B细胞也可能在眼内进行各种免疫调节活动。本综述总结了B细胞参与非感染性葡萄膜炎的证据，并考虑了B细胞对疾病发展和控制的潜在贡献。B细胞和/或其产物的操作是治疗非感染性葡萄膜炎的新方法。
Non-infectious uveitis—or intraocular inflammatory disease—causes substantial visual morbidity and reduced quality of life amongst affected individuals. To date, research of pathogenic mechanisms has largely been focused on processes involving T lymphocyte and/or myeloid leukocyte populations. Involvement of B lymphocytes has received relatively little attention. In contrast, B-cell pathobiology is a major field within general immunological research, and large clinical trials have showed that treatments targeting B cells are highly effective for multiple systemic inflammatory diseases. B cells, including the terminally differentiated plasma cell that produces antibody, are found in the human eye in different forms of non-infectious uveitis; in some cases, these cells outnumber other leukocyte subsets. Recent case reports and small case series suggest that B-cell blockade may be therapeutic for patients with non-infectious uveitis. As well as secretion of antibody, B cells may promote intraocular inflammation by presentation of antigen to T cells, production of multiple inflammatory cytokines and support of T-cell survival. B cells may also perform various immunomodulatory activities within the eye. This translational review summarizes the evidence for B-cell involvement in non-infectious uveitis, and considers the potential contributions of B cells to the development and control of the disease. Manipulations of B cells and/or their products are promising new approaches to the treatment of non-infectious uveitis.