LncRNA-HOTAIR and tumor metabolic reprogramming
LncRNA-HOTAIR and tumor metabolic reprogramming
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LncRNA-HOTAIR 与肿瘤代谢重编程
DOI：
10.3760/cma.j.issn.1673-4386.2018.06.009
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Li Na
中科院分区：
文献类型：
--
作者：
Cheng Meiyu;Zheng Xinzi;Li Na
LncRNA HOX转录反义RNA HOTAIR是一种由2158个核苷酸组成的长链非编码RNA。虽然它不编码蛋白质，但它通过修饰染色质结构在基因调控中发挥重要作用。已有研究表明，HOTAIR与多种人类癌症相关，其高表达促进肿瘤的发生发展，并与癌症预后不良和化疗耐药有关。HOTAIR与miR-34a、miR-454-3p、miR-197、miR-138、miR-203等microrna相互作用参与肿瘤发生。代谢重编程是肿瘤的十大特征之一，改变肿瘤代谢模式已成为肿瘤治疗的新靶点。HOTAIR在肿瘤代谢重编程中的作用越来越受到关注，它可以通过调节GLUT1、mTOR、SirT1、HK2、GLS、UQCRQ影响肿瘤糖代谢、谷氨酰胺代谢、线粒体代谢。了解HOTAIR在肿瘤代谢重编程中的具体机制，有助于了解肿瘤发生发展的机制，为肿瘤的筛查、诊断、治疗和预防提供新的方向。
LncRNA HOX transcriptional antisense RNA, HOTAIR, is a long noncoding RNA composed of 2158 nucleotides. Although it does not encode protein, it plays an important role in gene regulation by modifying chromatin structure. It has been shown that HOTAIR is associated with a variety of human cancers, and its high expression promotes the occurrence and development of tumor, and is related to the poor prognosis of cancer and chemotherapy resistance. The mutual interaction of HOTAIR with microRNAs including miR-34a, miR-454-3p, miR-197, miR-138, miR-203, is participated in tumorigenesis. Metabolic reprogramming is one of the ten major characteristics of tumor, and converting the mode of tumor metabolism has become a new target for cancer therapy. There is increasing attention to the role of HOTAIR in tumor metabolic reprogramming, it can influence tumorous glycometabolism, glutamine metabolism, mitochondrial metabolism through the regulation of GLUT1, mTOR, SirT1, HK2, GLS, UQCRQ. Understanding the specific mechanisms of HOTAIR in tumor metabolic reprogramming contributes to the understanding the mechanisms of tumorigenesis and development and provides a new direction for cancer screening, diagnosis, treatment and prevention.
Key words:
LncRNA; HOTAIR; Cancer; Glycometabolism; Glutamine; Mitochondrial