Calcitonin gene-related peptide inhibits acid secretion without modifying blood flow.
Calcitonin gene-related peptide inhibits acid secretion without modifying blood flow.
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降钙素基因相关肽抑制酸分泌而不改变血流。
DOI：
10.1152/ajpgi.1987.252.2.g215
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Guth,PH
中科院分区：
文献类型：
--
作者：
Leung,FW;Tallos,EG;Tache,YF;Guth,PH
降钙素基因相关肽（CGRP）是一种存在于中枢和周围神经系统的37-残基肽。根据以往报道CGRP定位于血管平滑肌相关纤维，并对胃酸分泌有明显抑制作用，我们研究了静脉输注CGRP对大鼠胃粘膜血流的影响。采用氢气清除技术测定尿素麻醉大鼠粘膜血流量。静脉滴注剂量为1或10微克X kg-1 X h-1的CGRP没有显著改变胃基底黏膜血流量或平均动脉血压。五胃泌素输注（20微克X kg-1 X h-1）刺激胃酸分泌，CGRP输注（10微克X kg-1 X h-1）抑制胃酸分泌，而胃体黏膜血流量和平均动脉血压均未发生显著变化。说明CGRP对胃酸分泌的抑制作用可能不是通过减少胃黏膜血流量的机制发挥的。
Calcitonin gene-related peptide (CGRP) is a 37-residue peptide present in the central and peripheral nervous system. Based on previous reports of its localization in fibers associated with vascular smooth muscles of vessels and its potent inhibitory effect on acid secretion, we studied the influence of intravenous infusion of rat CGRP on gastric mucosal blood flow. The hydrogen gas-clearance technique was used to measure mucosal blood flow in urethan-anesthetized rats. CGRP infused intravenously in doses of 1 or 10 micrograms X kg-1 X h-1 did not significantly modify basal gastric corpus mucosal blood flow or mean-arterial blood pressure. Gastric acid secretion stimulated by pentagastrin infusion (20 micrograms X kg-1 X h-1) was suppressed by CGRP administration (10 micrograms X kg-1 X h-1), whereas neither gastric corpus mucosal blood flow nor mean arterial blood pressure were significantly changed. These results indicate that CGRP must exert its inhibitory action on gastric acid secretion by a mechanism other than decreasing gastric mucosal blood flow.